HMM Summary Page: TIGR04363

FunctionFxLD family lantipeptide
Gene SymbolfxlA
Trusted Cutoff30.00
Domain Trusted Cutoff30.00
Noise Cutoff25.00
Domain Noise Cutoff25.00
Isology Typesubfamily
HMM Length37
AuthorHaft DH
Entry DateJul 23 2012 5:20PM
Last ModifiedJul 25 2012 4:21PM
CommentMembers of this protein family occur with a cassette of lanthionine-type peptide modification enzymes. Members are small (about 60 amino acids long), rich in Cys, and variable in copy number per genome (from one to three). These features suggest that members of this family are modified to become lantipeptides, although not necessarily a lantibiotic. There is no GlyGly cleavage motif to separate a leader peptide from core region.The considerable abundance in Streptomyces and relatively strong consideration hints at a non-antibiotic function. The motif FxLD in the N-terminal region is nearly invariant.
Genome PropertyGenProp1069: FxLD lantipeptide system (HMM)