| Accession | TIGR04365 |
| Name | spare_glycyl |
| Function | autonomous glycyl radical cofactor GrcA |
| Gene Symbol | grcA |
| Trusted Cutoff | 170.00 |
| Domain Trusted Cutoff | 170.00 |
| Noise Cutoff | 160.00 |
| Domain Noise Cutoff | 160.00 |
| Isology Type | equivalog |
| HMM Length | 126 |
| Author | Haft DH |
| Entry Date | Aug 5 2012 5:13PM |
| Last Modified | Aug 12 2012 6:56PM |
| Comment | This small protein, previously designated YfiD in E. coli, is closely homologous to pyruvate formate_lyase (PFL) in a region surrounding the stable glycyl radical that is prepared by the action of pyruvate formate-lyase activase, a radical SAM enzyme. When damage at the site of this radical breaks the main chain of PFL, this protein acts as a spare part that reintroduces the needed stable glycyl radical. Cutoffs for this model are set to exclude a set of closely related phage proteins that appear to have a corresponding function. |
| References | RN [1]
RM PMID:11444864
RT YfiD of Escherichia coli and Y06I of bacteriophage T4 as autonomous glycyl radical cofactors reconstituting the catalytic center of oxygen-fragmented pyruvate formate-lyase.
RA Wagner AF, Schultz S, Bomke J, Pils T, Lehmann WD, Knappe J
RL Biochem Biophys Res Commun. 2001 Jul 13;285(2):456-62. |
| Genome Property | GenProp0943: pyruvate formate-lyase system (HMM) |
