HMM Summary Page: TIGR04446

Functionprenylated cyclic peptide, anacyclamide/piricyclamide family
Trusted Cutoff35.00
Domain Trusted Cutoff35.00
Noise Cutoff31.00
Domain Noise Cutoff31.00
Isology Typesubfamily
HMM Length51
AuthorHaft DH
Entry DateJun 5 2013 8:36PM
Last ModifiedJun 5 2013 8:36PM
CommentMembers of this protein family occur primarily in Cyanobacteria. They average about 50 residues in length and are the ribosomally translated precursors of peptide natural products whose modifications include cleavage, cyclization, and prenylation. Sequences are well-conserved in the N-terminal region. They are nearly invariant over the last eight residues, but hypervariable just before that stretch. A related family, often in a similar genome context, is TIGR03678.
ReferencesRN [1] RM PMID:21766822 RT Enzymatic basis of ribosomal peptide prenylation in cyanobacteria. RA McIntosh JA, Donia MS, Nair SK, Schmidt EW RL J Am Chem Soc. 2011 Aug 31;133(34):13698-705.
Genome PropertyGenProp1083: cyanobactin-like ribosomal natural product biosynthesis (HMM)