HMM Summary Page: TIGR04458
| Accession | TIGR04458 |
| Name | CYP450_TxtE |
| Function | 4-nitrotryptophan synthase |
| Gene Symbol | txtE |
| Trusted Cutoff | 500.00 |
| Domain Trusted Cutoff | 500.00 |
| Noise Cutoff | 250.00 |
| Domain Noise Cutoff | 250.00 |
| Isology Type | equivalog |
| EC Number | 1.-.-.- |
| HMM Length | 403 |
| Author | Haft DH |
| Entry Date | Jun 29 2013 5:57PM |
| Last Modified | Jun 29 2013 5:57PM |
| Comment | Members of this family are cytochrome P450 enzymes that convert L-tryptophan into L-4-nitrotryptophan. In thaxtomin gene clusters, this enzyme (TxtE) uses nitric acid (NO) derived from arginine by the nitric oxide synthase TxtD, and O2, to perform the tryptophan nitration. L-4-nitrotryptophan is then used as a non-proteinogenic amino acid by non-ribosomal peptide synthases (NRPS). |
| References | RN [1] RM PMID:22941045 RT Cytochrome P450-catalyzed L-tryptophan nitration in thaxtomin phytotoxin biosynthesis. RA Barry SM, Kers JA, Johnson EG, Song L, Aston PR, Patel B, Krasnoff SB, Crane BR, Gibson DM, Loria R, Challis GL RL Nat Chem Biol. 2012 Oct;8(10):814-6. |