HMM Summary Page: TIGR04459

Functiontype I toxin-antitoxin system toxin TisB
Gene SymboltisB
Trusted Cutoff38.00
Domain Trusted Cutoff38.00
Noise Cutoff25.00
Domain Noise Cutoff25.00
Isology Typeequivalog
HMM Length29
AuthorHaft DH
Entry DateJul 12 2013 2:11PM
Last ModifiedJul 12 2013 2:11PM
CommentMembers of this family are the TisB toxin protein of a type I toxin-antitoxin system, meaning that the antitoxin is a non-coding RNA. TisB is induced by some types of stress (SOS, ciprofloxacin) and appears to induce a persister state by dissipating transmembrane potential, thus depleting ATP. Persister cells, unable to grow until the persister state changes, survive a number of challenges, including exposure to most antibiotics.
ReferencesRN [1] RM PMID:18761622 RT A small SOS-induced toxin is targeted against the inner membrane in Escherichia coli. RA Unoson C, Wagner EG RL Mol Microbiol. 2008 Oct;70(1):258-70. doi: 10.1111/j.1365-2958.2008.06416.x. RN [2] RM PMID:23062338 RT Peptide-lipid interactions of the stress-response peptide TisB that induces bacterial persistence. RA Steinbrecher T, Prock S, Reichert J, Wadhwani P, Zimpfer B, Burck J, Berditsch M, Elstner M, Ulrich AS RL Biophys J. 2012 Oct 3;103(7):1460-9. doi: 10.1016/j.bpj.2012.07.060. RN [3] RM PMID:22728134 RT Persister-promoting bacterial toxin TisB produces anion-selective pores in planar lipid bilayers. RA Gurnev PA, Ortenberg R, Dorr T, Lewis K, Bezrukov SM RL FEBS Lett. 2012 Jul 30;586(16):2529-34. doi: 10.1016/j.febslet.2012.06.021.
Genome PropertyGenProp1091: toxin-antitoxin system, type I (HMM)