HMM Summary Page: TIGR04460

Functionenduracididine biosynthesis enzyme MppR
Gene SymbolmppR
Trusted Cutoff380.00
Domain Trusted Cutoff380.00
Noise Cutoff240.00
Domain Noise Cutoff240.00
Isology Typeequivalog
HMM Length257
AuthorHaft DH
Entry DateJul 16 2013 4:28PM
Last ModifiedJul 16 2013 4:28PM
CommentMembers of this family are MppR, one of three enzymes involved in synthesizing enduracididine, a non-proteinogenic amino acid used in non-ribosomal peptide synthases to make natural products such as enduracidin from Streptomyces fungicidicus ATCC 21013. MppR is belongs to the acetoacetate decarboxylase-like superfamily. MppR catalyzes an aldol condensation and a dehydration, not a decarboxylation.
ReferencesRN [1] RM PMID:23758195 RT Structural and Functional Characterization of MppR, an Enduracididine Biosynthetic Enzyme from Streptomyces hygroscopicus: Functional Diversity in the Acetoacetate Decarboxylase-like Superfamily. RA Burroughs AM, Hoppe RW, Goebel NC, Sayyed BH, Voegtline TJ, Schwabacher AW, Zabriskie TM, Silvaggi NR RL Biochemistry. 2013 Jul 2;52(26):4492-506. doi: 10.1021/bi400397k.
Genome PropertyGenProp1084: enduracididine biosynthesis (HMM)