HMM Summary Page: TIGR04467

Functionhydroxymethylcytosylglucuronate/cytosylglucuronate synthase
Trusted Cutoff300.00
Domain Trusted Cutoff300.00
Noise Cutoff100.00
Domain Noise Cutoff100.00
Isology Typeequivalog
EC Number2.4.1.-
HMM Length382
AuthorHaft DH
Entry DateAug 17 2013 3:14PM
Last ModifiedAug 17 2013 3:14PM
CommentMembers of this family synthesize cytosylglucuronate (or hydroxymethylcytosylglucuronate) from UDP-glucuronate and free cytosine (or hydroxymethylcytosine). This reaction is followed by a decarboxylation at C5 of the glucoside residue. The net reaction makes the pyranoside core moiety of a class of peptidyl nucleoside antibiotics.
ReferencesRN [1] RM PMID:22753012 RT Analysis of the mildiomycin biosynthesis gene cluster in Streptoverticillum remofaciens ZJU5119 and characterization of MilC, a hydroxymethyl cytosyl-glucuronic acid synthase. RA Wu J, Li L, Deng Z, Zabriskie TM, He X RL Chembiochem. 2012 Jul 23;13(11):1613-21. doi: 10.1002/cbic.201200173.
Genome PropertyGenProp1085: pyranoside core peptidyl nucleoside antibiotic biosynthesis (HMM)