Accession | TIGR04469 |
Name | CGA_synth_rel |
Function | CGA synthase-related protein |
Gene Symbol | blsF |
Trusted Cutoff | 150.00 |
Domain Trusted Cutoff | 150.00 |
Noise Cutoff | 50.00 |
Domain Noise Cutoff | 50.00 |
Isology Type | equivalog |
HMM Length | 297 |
Author | Haft DH |
Entry Date | Aug 18 2013 9:15PM |
Last Modified | Aug 18 2013 9:15PM |
Comment | Members of this family are related to cytosylglucuronate (CGA) synthase (TIGR04466), and found in the same clusters as CGA synthase and CGA decarboxylase. These clusters produce peptidyl nucleoside antibiotics with a pyranoside core moiety, found in a number of Streptomyces species. Removal of the S. griseochromogenes member of this family, BlsF, from a heterologous expression system caused an increase, not blockage, of blasticidin S. |
References | RN [1]
RM PMID:23377931
RT Streptomyces lividans blasticidin S deaminase and its application in engineering a blasticidin S-producing strain for ease of genetic manipulation.
RA Li L, Wu J, Deng Z, Zabriskie TM, He X
RL Appl Environ Microbiol. 2013 Apr;79(7):2349-57. doi: 10.1128/AEM.03254-12. |