HMM Summary Page: TIGR04498

Functionabortive infection protein, AbiV family
Trusted Cutoff27.00
Domain Trusted Cutoff26.00
Noise Cutoff23.00
Domain Noise Cutoff23.00
Isology Typesubfamily
HMM Length143
AuthorHaft DH
Entry DateDec 5 2013 1:55PM
Last ModifiedDec 5 2013 1:55PM
CommentThis family includes AbiV (abortive infection system V) from Lactococcus lactis, a phage resistance protein that causes certain phage infections to fail to lead to successful phage replication. Abortive infection mechanisms differ greatly. AbiV interacts directly with the protein SaV in phage p2 and blocks translation of phage proteins.
ReferencesRN [1] RM PMID:20851990 RT Lactococcal abortive infection protein AbiV interacts directly with the phage protein SaV and prevents translation of phage proteins. RA Haaber J, Samson JE, Labrie SJ, Campanacci V, Cambillau C, Moineau S, Hammer K RL Appl Environ Microbiol. 2010 Nov;76(21):7085-92. doi: 10.1128/AEM.00093-10.
Genome PropertyGenProp1093: abortive infection proteins (HMM)