Accession | TIGR04507 |
Name | fluorinase |
Function | adenosyl-fluoride synthase |
Trusted Cutoff | 400.00 |
Domain Trusted Cutoff | 400.00 |
Noise Cutoff | 225.00 |
Domain Noise Cutoff | 225.00 |
Isology Type | equivalog |
EC Number | 2.5.1.63 |
HMM Length | 286 |
Author | Haft DH |
Entry Date | Jan 20 2014 12:05AM |
Last Modified | Jan 20 2014 12:05AM |
Comment | Members of this family are fluorinase (adenosyl-fluoride synthase, EC 2.5.1.63), an enzyme involved in the first committed step in the biosynthesis of at least two different organofluorine compounds. Few organofluorine natural products are known. Related enzymes include chlorinases (EC 2.5.1.94) that lack fluorinase activity, although a fluorinase may show chlorinase activity. |
References | RN [1]
RM PMID:16604208
RT Substrate specificity in enzymatic fluorination. The fluorinase from Streptomyces cattleya accepts 2'-deoxyadenosine substrates.
RA Cobb SL, Deng H, McEwan AR, Naismith JH, O'Hagan D, Robinson DA
RL Org Biomol Chem. 2006 Apr 21;4(8):1458-60. |