HMM Summary Page: TIGR04515
| Accession | TIGR04515 |
| Name | P450_rel_GT_act |
| Function | P450-derived glycosyltranferase activator |
| Trusted Cutoff | 343.00 |
| Domain Trusted Cutoff | 343.00 |
| Noise Cutoff | 280.00 |
| Domain Noise Cutoff | 280.00 |
| Isology Type | subfamily |
| HMM Length | 386 |
| Author | Haft DH |
| Entry Date | Mar 4 2014 2:18PM |
| Last Modified | Sep 16 2014 4:02PM |
| Comment | Members of this family resemble cytochrome P450 by homolog, but lack a critical heme-binding Cys residue. Members in general are encoded next to a glycosyltransferase gene in a natural products biosynthesis cluster, physically interact with it, and help the glycosyltransferase achieve high specificity while retaining high activity. Many members of this family assist in the attachment of a sugar moiety to a natural product such as a polyketide. |
| References | RN [1] RM PMID:22056329 RT Structure of the glycosyltransferase EryCIII in complex with its activating P450 homologue EryCII. RA Moncrieffe MC, Fernandez MJ, Spiteller D, Matsumura H, Gay NJ, Luisi BF, Leadlay PF RL J Mol Biol. 2012 Jan 6;415(1):92-101. doi: 10.1016/j.jmb.2011.10.036. |