Comment | Members of this family, including MG_281 of Mycoplasma genitalium, bind conserved regions of the IgG light chain sequences, blocking IgG's normal function of antigen-specific binding. It is therefore an important virulence protein. Members of this family are found also in Mycoplasma pneumoniae, M. penetrans, M. gallisepticum, and M. iowae. Model TIGR04524 describes a region within this protein that is shared by many additional Mycoplasma and Ureaplasma proteins. |
References | RN [1]
RM PMID:24503852
RT A structurally distinct human mycoplasma protein that generically blocks antigen-antibody union.
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RL Science. 2014 Feb 7;343(6171):656-61. doi: 10.1126/science.1246135. |