Comment | This extremely rare protein family, a branch of the 2-oxoglutarate dependent oxygenase family related to proline 3-hydroxylase, appears only in natural product biosynthetic clusters that include nonribosomal peptide synthases. One members is PlyP from the polyoxypeptin A cluster, suggested to hydroxylate 3-methylproline. Another, GetF from the GE81112 biosynthetic gene cluster, is a proposed to hydroxylate pipecolic acid. |
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RT Identification and characterization of the biosynthetic gene cluster of polyoxypeptin A, a potent apoptosis inducer.
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RT Insights into an unusual nonribosomal peptide synthetase biosynthesis: identification and characterization of the GE81112 biosynthetic gene cluster.
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RL J Biol Chem. 2010 Oct 22;285(43):32710-9. doi: 10.1074/jbc.M110.146803. |