Accession | TIGR04532 |
Name | PT_fungal_PKS |
Function | polyketide product template domain |
Trusted Cutoff | 168.00 |
Domain Trusted Cutoff | 168.00 |
Noise Cutoff | 165.00 |
Domain Noise Cutoff | 165.00 |
Isology Type | subfamily_domain |
HMM Length | 329 |
Author | Haft DH |
Entry Date | May 6 2014 1:52PM |
Last Modified | Sep 16 2014 4:02PM |
Comment | Sequences found by this model are the so-called product template (PT) domain of various fungal iterative type I polyketide synthases. This domain resembles PF14765, designated polyketide synthase dehydratase by Pfam, but members of that family are primarily bacterial, where type I PKS are predominantly modular, not iterative. The dehydratase active site residues well-conserved in PF14765 (His in the first hot dog domain, Asp in the second hot dog domain) seem well conserved in this family also. |
References | RN [1]
RM PMID:20479000
RT Classification, prediction, and verification of the regioselectivity of fungal polyketide synthase product template domains.
RA Li Y, Image II, Xu W, Image I, Tang Y, Image I
RL J Biol Chem. 2010 Jul 23;285(30):22764-73. |