HMM Summary Page: TIGR04541
Accession | TIGR04541 |
Name | thiaminase_BcmE |
Function | thiamine pyridinylase |
Gene Symbol | bcmE |
Trusted Cutoff | 175.00 |
Domain Trusted Cutoff | 175.00 |
Noise Cutoff | 50.00 |
Domain Noise Cutoff | 50.00 |
Isology Type | equivalog |
EC Number | 2.5.1.2 |
HMM Length | 381 |
Author | Haft DH |
Entry Date | Jun 20 2014 4:25PM |
Last Modified | Jun 20 2014 4:25PM |
Comment | Members of this family are thiamine pyridinylase (EC 2.5.1.2), also called thiaminase I. Most examples of this secreted, thiamine-degrading enzyme are encoded with a cluster for biosynthesis of the thiamine antivitamin bacimethrin. |
References | RN [1] RM PMID:8631946 RT Mechanistic studies on thiaminase I. Overexpression and identification of the active site nucleophile. RA Costello CA, Kelleher NL, Abe M, McLafferty FW, Begley TP RL J Biol Chem. 1996 Feb 16;271(7):3445-52. RN [2] RM PMID:24654570 RT Biosynthesis of a thiamin antivitamin in Clostridium botulinum. RA Cooper LE, O'Leary SE, Begley TP RL Biochemistry. 2014 Apr 15;53(14):2215-7. doi: 10.1021/bi500281a. |
Genome Property | GenProp1097: bacimethrin biosynthesis (HMM) |