Research Interests and Accomplishments
Dr. Methé is a Professor in the Departments of Human Genome Medicine and Microbial and Environmental Genomics at the J. Craig Venter Institute (JCVI). Dr. Methé has extensive experience in genomics, metagenomics, microbial ecology and physiology and handling large data sets from high throughput functional genomic methodologies including gene expression studies. She was Principal Investigator on the Geobacter sulfurreducens, Colwellia psychrerythraea 34H and Klebsiella pneumoniae 342 genome projects and led an EST and annotation refinement project of the model protozoa, Tetrahymena thermophila. She has participated in numerous annotation and comparative genome analyses of diverse prokaryotes such as Shewanella oneidensis, Desulfovibrio vulgaris, Methylococcus capsulatus and Dehalococcoides ethenogenes.
Currently, Dr. Methé is a Co-Investigator of the Human Microbiome Project (HMP) ongoing at the JCVI for which she has served as the Co-Chair for the Manual of Procedures and is currently Co-Chair of the Metagenomics/Data Generation/Data Analysis Working Groups for the HMP consortium. Dr. Methé is also leading an effort in which metagenomic approaches are being applied to a study designed to investigate links between the human microbiome and psoriasis. Dr. Methé is also currently PI on a project to sequence and use microarray technology to analyze gene expression of the piezophile, Colwellia sp. MT41 and she is leading a comparative and functional genomics project to uncover virulence factors in fourteen serovars of Ureaplasma parvum and U. urealyticum. As part of an award with the DOE: Genomes to Life program, she is also leading an effort to apply functional genomics methodologies, such as microarray technology, to the study of Geobacter sulfurreducens gene expression and a metagenomic and metatranscriptomic study of a uranium contaminated subsurface environment undergoing bioremediation.