JCVI: About / Bios / Charles E. Merryman
 
 
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About

Biographies

Charles E. Merryman, Ph.D.
Assistant Professor

Research Interests and Accomplishments

Dr. Merryman's group is interested in tailoring the metabolism of synthetic cells. The lab employs a wide range of biochemical, molecular, and evolutionary approaches for the de novo construction of entire genomes and their subsequent evaluation. Methods for parallel genome assembly are being developed so that millions of rival genomic designs can be tested to identify those with the metabolic circuitry necessary for high-level compound production.

Previously, as a scientist with the Howard Hughes Medical Institute and as a postdoctoral researcher at M.I.T., Dr. Merryman developed methods for creating libraries of drug-like molecules and identifying desirable members through Mendelian evolution. Dr. Merryman holds bachelor's and master's degree's in chemistry and biophysics from the University of Montana, and a Ph.D. in molecular biology from the University of California at Santa Cruz.

Select Publications

Hutchison CA, Chuang RY, et al.
Design and Synthesis of a Minimal Bacterial Genome.

Science (New York, N.Y.). 2016 Mar 25; 351: aad6253.[more]

Gibson, D. G., Benders, G. A., et al.
Complete Chemical Synthesis, Assembly, and Cloning of a Mycoplasma genitalium Genome

Science. 2008 Jan 24; 319(5867): 1215-20.[more]

Merryman, C., Green, R.
Method for Producing Diverse Libraries of Encoded Non-standard Polymers Using Aminoacyl TRNA Analogs for Screening a Desired Activity, Including Drugs

2004 Oct 14;(0)[more]

Merryman, C., Green, R.
Transformation of Aminoacyl TRNAs for the In Vitro Selection of "drug-like" Molecules

Chem Biol. 2004 Apr 01; 11(4): 575-82.[more]

Merryman, C., Bartel, D.P.
Method for Producing Diverse Libraries of Encoded Polypeptides

2002 Aug 02;[more]

Merryman, C., Weinstein, E., et al.
A Bifunctional TRNA for In Vitro Selection

Chem Biol. 2002 Jun 01; 9(6): 741-6.[more]

Merryman, C., Moazed, D., et al.
Nucleotides In 23S RRNA Protected by the Association of 30S and 50S Ribosomal Subunits

J Mol Biol. 1999 Jan 08; 285(1): 107-13.[more]

Merryman, C., Moazed, D., et al.
Nucleotides In 16S RRNA Protected by the Association of 30S and 50S Ribosomal Subunits

J Mol Biol. 1999 Jan 08; 285(1): 97-105.[more]