About
Biographies
Research Interests and Accomplishments
David M. Tanenbaum is a Bioinformatics Team Lead in the Informatics Department at the J. Craig Venter Institute. He joined JCVI in December 2007 after six years at Celera, a commercial entity also started by Dr. Venter in the 1990s. He has extensive genomics experience, including SNP discovery and oncogenomics.
His interests include how the composition of microfloral communities in the human body can impact the clinical efficacy of treatments for cancer and immunological diseases. Additional research interests include pathogen genomics for biodefense applications and the evolutionary biology of extremophiles.
Dr. Tanenbaum graduated from The University of Virginia with a B.A. in Chemistry in 1992, and Yale Univerity with a Ph.D. in Molecular Biophysics and Biochemistry in 1998. He subsequently obtained a joint post-doctoral fellowship at Harvard Medical School and The Dana-Farber Cancer Institute.
Select Publications
Bustamante, C. D., Fledel-Alon, A., et al.
Natural selection on protein-coding genes in the human genome
Nature. 2005 Oct 20; 437(7062): 1153-7.
Nielsen, R., Bustamante, C., et al.
A scan for positively selected genes in the genomes of humans and chimpanzees
PLoS Biol. 2005 Jun 01; 3(6): e170.
Wang, Z. C., Lin, M., et al.
Loss of heterozygosity and its correlation with expression profiles in subclasses of invasive breast cancers
Cancer Res. 2004 Jan 01; 64(1): 64-71.
Clark, A. G., Glanowski, S., et al.
Inferring nonneutral evolution from human-chimp-mouse orthologous gene trios
Science. 2003 Dec 12; 302(5652): 1960-3.
Weber, G., Shendure, J., et al.
Identification of foreign gene sequences by transcript filtering against the human genome
Nat Genet. 2002 Feb 01; 30(2): 141-2.
Lindblad-Toh, K., Tanenbaum, D. M., et al.
Loss-of-heterozygosity analysis of small-cell lung carcinomas using single-nucleotide polymorphism arrays
Nat Biotechnol. 2000 Sep 01; 18(9): 1001-5.
Tanenbaum, D. M., Wang, Y., et al.
Crystallographic comparison of the estrogen and progesterone receptor's ligand binding domains
Proc Natl Acad Sci U S A. 1998 May 26; 95(11): 5998-6003.