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About

Biographies

David Wentworth, Ph.D.
Associate Professor

Research Interests and Accomplishments

Dr. Wentworth is the director of viral programs at J. Craig Venter Institute. The goals of his team's research are to understand viral evolution (particularly adaptation of viruses to a new host), to identify molecular determinants that affect the transmission or pathogenesis of the virus, and to use this information to create/develop vaccines and/or antivirals. His previous studies have focused on the transmission of swine viruses to humans, highly pathogenic H5 influenza viruses, coronavirus-host interactions, and emergence of new human pathogens (e.g., H1N1 pandemic, and SARS-CoV). His team continues to study mechanisms of pathogenesis and evolution of influenza A viruses, and coronaviruses such as SARS-CoV, and they are creating and analyzing novel vaccines against influenza A viruses. Dr. Wentworth received his doctorate in virology studying influenza at the University of Wisconsin-Madison. He studied coronaviruses as a postdoctoral fellow, and later as an instructor at the University of Colorado Health Sciences Center in Denver. He was the Director of the Influenza Virus and Coronavirus Pathogenesis laboratory at the Wadsworth Center, NYSDOH, and an Assistant Professor at the State University of New York-Albany prior to joining JCVI. Dr. Wentworth has also taught virology and microbiology to undergraduate, graduate, veterinary and medical students.

Select Publications

Westgeest KB, Russell CA, et al.
Genomewide Analysis of Reassortment and Evolution of Human Influenza A(H3N2) Viruses Circulating Between 1968 and 2011.

Journal of Virology. 2014 Mar 01; 88: 2844-57.[more]

Le MQ, Lam HM, et al.
Migration and Persistence of Human Influenza a Viruses, Vietnam, 2001-2008.

Emerging infectious Diseases. 2013 Nov 01; 19: 1756-65.[more]

Boyce WM, Schobel S, et al.
Complete Genome Sequence of a Reassortant H14N2 Avian Influenza Virus from California.

Genome Announcements. 2013 Sep 01; 1[more]

Lindsay LL, Kelly TR, et al.
Avian Influenza: Mixed Infections and Missing Viruses.

Viruses. 2013 Sep 01; 5: 1964-77.[more]

Hauser MJ, Dlugolenski D, et al.
Antiviral Responses by Swine Primary Bronchoepithelial Cells Are Limited Compared to Human Bronchoepithelial Cells Following Influenza Virus Infection.

PloS One. 2013 Jul 01; 8: e70251.[more]

Hall JS, Teslaa JL, et al.
Evolution of a Reassortant North American Gull Influenza Virus Lineage: Drift, Shift and Stability.

Virology Journal. 2013 Jun 06; 10: 179.[more]

Depew J, Zhou B, et al.
Sequencing Viral Genomes from a Single Isolated Plaque.

Virology Journal. 2013 Jun 06; 10: 181.[more]

Zhou B, Pearce MB, et al.
Asparagine Substitution at PB2 Residue 701 Enhances the Replication, Pathogenicity, and Transmission of the 2009 Pandemic H1N1 Influenza A Virus.

PloS One. 2013 Jun 01; 8: e67616.[more]

Dormitzer PR, Suphaphiphat P, et al.
Synthetic Generation of Influenza Vaccine Viruses for Rapid Response to Pandemics.

Science Translational Medicine. 2013 May 15; 5: 185ra68.[more]

Saira K, Lin X, et al.
Sequence Analysis of In Vivo Defective-interfering (DI)-like RNA of Influenza A H1N1 Pandemic Virus.

Journal of Virology. 2013 May 15;[more]

Zhou B, Li Y, et al.
Engineering Temperature Sensitive Live Attenuated Influenza Vaccines from Emerging Viruses.

Vaccine. 2012 May 21; 30: 3691-702.[more]

Zhou, B., Jerzak, G., et al.
Reverse Genetics Plasmid for Cloning Unstable Influenza A Virus Gene Segments

J Virol Methods. 2011 May 01; 173(2): 378-83.[more]

Ghedin, E., Laplante, J., et al.
Deep Sequencing Reveals Mixed Infection With 2009 Pandemic Influenza A (H1N1) Virus Strains and the Emergence of Oseltamivir Resistance.

The Journal of infectious diseases. 2011 Jan 15; 203(2): 168-74.[more]

Zhou, B., Li, Y., et al.
PB2 Residue 158 Is a Pathogenic Determinant of Pandemic H1N1 and H5 Influenza a Viruses In Mice

J Virol. 2011 Jan 01; 85(1): 357-65.[more]

Zhou, B., Li, Y., et al.
NS-based Live Attenuated H1N1 Pandemic Vaccines Protect Mice and Ferrets.

Vaccine. 2010 Nov 23; 28(50): 8015-25.[more]

Zhou, B., Li, Y., et al.
PB2 Residue 158 Is a Pathogenic Determinant of Pandemic-H1N1 and H5 Influenza A Viruses In Mice

J Virol. 2010 Oct 20;[more]

Ghedin, E., Wentworth, D. E., et al.
Unseasonal Transmission of H3N2 Influenza A Virus During the Swine-origin H1N1 Pandemic.

Journal of virology. 2010 Jun 01; 84(11): 5715-8.[more]

Zhou, B., Donnelly, M. E., et al.
Single-reaction Genomic Amplification Accelerates Sequencing and Vaccine Production for Classical and Swine Origin Human Influenza a Viruses

J Virol. 2009 Oct 01; 83(19): 10309-13.[more]

Wentworth, D. E., Tresnan, D. B., et al.
Cells of Human Aminopeptidase N (CD13) Transgenic Mice Are Infected by Human Coronavirus-229E In Vitro, but Not In Vivo

Virology. 2005 May 10; 335(2): 185-97.[more]

Jeffers, S. A., Tusell, S. M., et al.
CD209L (L-SIGN) Is a Receptor for Severe Acute Respiratory Syndrome Coronavirus

Proc Natl Acad Sci U S A. 2004 Nov 02; 101(44): 15748-53.[more]

Gillim-Ross, L., Taylor, J., et al.
Discovery of Novel Human and Animal Cells Infected by the Severe Acute Respiratory Syndrome Coronavirus by Replication-specific Multiplex Reverse Transcription-PCR

J Clin Microbiol. 2004 Jul 01; 42(7): 3196-206.[more]

Wentworth, D. E., Gillim-Ross, L., et al.
Mice Susceptible to SARS Coronavirus

Emerg Infect Dis. 2004 Jul 01; 10(7): 1293-6.[more]

Bonavia, A., Zelus, B. D., et al.
Identification of a Receptor-binding Domain of the Spike Glycoprotein of Human Coronavirus HCoV-229E

J Virol. 2003 Feb 01; 77(4): 2530-8.[more]

Wentworth, D. E., Holmes, K. V.
Molecular Determinants of Species Specificity In the Coronavirus Receptor Aminopeptidase N (CD13): Influence of N-linked Glycosylation

J Virol. 2001 Oct 01; 75(20): 9741-52.[more]

Wentworth, D. E., McGregor, M. W., et al.
Transmission of Swine Influenza Virus to Humans After Exposure to Experimentally Infected Pigs

J Infect Dis. 1997 Jan 01; 175(1): 7-15.[more]

Wentworth, D. E., Thompson, B. L., et al.
An Influenza A (H1N1) Virus, Closely Related to Swine Influenza Virus, Responsible for a Fatal Case of Human Influenza

J Virol. 1994 Apr 01; 68(4): 2051-8.[more]