About
Biographies
Research Interests and Accomplishments
Elisabet Caler is a Bioinformatics Manager in the Bioinformatics Department at the J. Craig Venter Institute. She currently leads the Eukaryotic Annotation Group, responsible for annotation and analysis of large, complex eukaryotic genomes. Her interests include microbial pathogenesis of eukaryotic parasites of public health importance, genome architecture, gene discovery and genome annotation, comparative genomics (focusing on the identification of pathogenesis factors), repeats and transposable element and metagenomics, among others.
Prior to joining J. Craig Venter Institute (when it was TIGR, in 2002), she was a postdoctoral fellow at NIAID in the laboratory of Dr. David Sacks, and before moving to the Washington DC area, she was a postdoctoral fellow at the Boyer Center for Molecular Medicine, in New Haven, Connecticut. She received her Ph.D. degree in Microbial Pathogenesis and Cell Biology from Yale University, where she studied the invasion mechanisms and signaling events during the infection of Trypanosoma cruzi to host cells.
Select Publications
Gillespie, J. J., Joardar, V., et al.
A rickettsia genome overrun by mobile genetic elements provides insight into the acquisition of genes characteristic of an obligate intracellular lifestyle
J Bacteriol. 2012 Jan 01; 194(2): 376-94.[more]
Fernandez Robledo, J. A., Caler, E., et al.
The search for the missing link: a relic plastid in Perkinsus?
International journal for parasitology. 2011 Oct 01; 41(12): 1217-29.[more]
Aurrecoechea, C., Barreto, A., et al.
AmoebaDB and MicrosporidiaDB: functional genomic resources for Amoebozoa and Microsporidia species
Nucleic Acids Res. 2011 Jan 01; 39: D612-9.[more]
Arensburger, P., Megy, K., et al.
Sequencing of Culex quinquefasciatus establishes a platform for mosquito comparative genomics
Science. 2010 Oct 01; 330(6000): 86-8.[more]
Cuvelier, M. L., Allen, A. E., et al.
Targeted metagenomics and ecology of globally important uncultured eukaryotic phytoplankton
Proc Natl Acad Sci U S A. 2010 Jul 28; 107(33): 14679-84.[more]
Kirkness, E. F., Haas, B. J., et al.
Genome sequences of the human body louse and its primary endosymbiont provide insights into the permanent parasitic lifestyle
Proc Natl Acad Sci U S A. 2010 Jun 21; 107(27): 12168-73.[more]
Guerrero, F. D., Moolhuijzen, P., et al.
Reassociation kinetics-based approach for partial genome sequencing of the cattle tick, Rhipicephalus (Boophilus) microplus
BMC Genomics. 2010 Jun 11; 11(1): 374.[more]
Lorenzi, H. A., Puiu, D., et al.
New Assembly, Reannotation and Analysis of the Entamoeba histolytica Genome Reveal New Genomic Features and Protein Content Information
PLoS Negl Trop Dis. 2010 Jun 01; 4(6): e716.[more]
Brinkac, L. M., Davidsen, T., et al.
Pathema: a clade-specific bioinformatics resource center for pathogen research
Nucleic Acids Res. 2009 Oct 20;[more]
Lorenzi, H., Thiagarajan, M., et al.
Genome wide survey, discovery and evolution of repetitive elements in three Entamoeba species
BMC Genomics. 2008 Dec 10; 9(1): 595.[more]
Carlton, J. M., Adams, J. H., et al.
Comparative genomics of the neglected human malaria parasite Plasmodium vivax
Nature. 2008 Oct 09; 455(7214): 757-63.[more]
Gilchrist, C. A., Baba, D. J., et al.
Targets of the Entamoeba histolytica Transcription Factor URE3-BP
PLoS Negl Trop Dis. 2008 Aug 01; 2(8): e282.[more]
Ghedin, E., Wang, S., et al.
Draft genome of the filarial nematode parasite Brugia malayi
Science. 2007 Sep 21; 317(5845): 1756-60.[more]
Sargeant, T. J., Marti, M., et al.
Lineage-specific expansion of proteins exported to erythrocytes in malaria parasites
Genome Biol. 2006 Feb 20; 7(2): R12.[more]
El-Sayed, N. M., Myler, P. J., et al.
Comparative genomics of trypanosomatid parasitic protozoa
Science. 2005 Jul 15; 309(5733): 404-9.[more]
Reddy, A., Caler, E. V., et al.
Plasma membrane repair is mediated by Ca(2+)-regulated exocytosis of lysosomes
Cell. 2001 Jul 27; 106(2): 157-69.[more]
Caler, E. V., Chakrabarti, S., et al.
The Exocytosis-regulatory protein synaptotagmin VII mediates cell invasion by Trypanosoma cruzi
J Exp Med. 2001 May 07; 193(9): 1097-104.[more]
Caler, E. V., Morty, R. E., et al.
Dual role of signaling pathways leading to Ca(2+) and cyclic AMP elevation in host cell invasion by Trypanosoma cruzi
Infect Immun. 2000 Dec 01; 68(12): 6602-10.[more]
Caler, E. V., Vaena de Avalos, S., et al.
Oligopeptidase B-dependent signaling mediates host cell invasion by Trypanosoma cruzi
Embo J. 1998 Sep 01; 17(17): 4975-86.[more]