
About
Biographies

Research Interests and Accomplishments
Elisabet Caler is a Bioinformatics Manager in the Bioinformatics Department at the J. Craig Venter Institute. She currently leads the Eukaryotic Annotation Group, responsible for annotation and analysis of large, complex eukaryotic genomes. Her interests include microbial pathogenesis of eukaryotic parasites of public health importance, genome architecture, gene discovery and genome annotation, comparative genomics (focusing on the identification of pathogenesis factors), repeats and transposable element and metagenomics, among others.
Prior to joining J. Craig Venter Institute (when it was TIGR, in 2002), she was a postdoctoral fellow at NIAID in the laboratory of Dr. David Sacks, and before moving to the Washington DC area, she was a postdoctoral fellow at the Boyer Center for Molecular Medicine, in New Haven, Connecticut. She received her Ph.D. degree in Microbial Pathogenesis and Cell Biology from Yale University, where she studied the invasion mechanisms and signaling events during the infection of Trypanosoma cruzi to host cells.
Select Publications
Ghedin, E., Wang, S., et al.
Draft genome of the filarial nematode parasite Brugia malayi
Science. 2007 Sep 21; 317(5845): 1756-60.
Sargeant, T. J., Marti, M., et al.
Lineage-specific expansion of proteins exported to erythrocytes in malaria parasites
Genome Biol. 2006 Feb 20; 7(2): R12.
El-Sayed, N. M., Myler, P. J., et al.
Comparative genomics of trypanosomatid parasitic protozoa
Science. 2005 Jul 15; 309(5733): 404-9.
Reddy, A., Caler, E. V., et al.
Plasma membrane repair is mediated by Ca(2+)-regulated exocytosis of lysosomes
Cell. 2001 Jul 27; 106(2): 157-69.
Caler, E. V., Chakrabarti, S., et al.
The Exocytosis-regulatory protein synaptotagmin VII mediates cell invasion by Trypanosoma cruzi
J Exp Med. 2001 May 07; 193(9): 1097-104.
Caler, E. V., Morty, R. E., et al.
Dual role of signaling pathways leading to Ca(2+) and cyclic AMP elevation in host cell invasion by Trypanosoma cruzi
Infect Immun. 2000 Dec 01; 68(12): 6602-10.
Caler, E. V., Vaena de Avalos, S., et al.
Oligopeptidase B-dependent signaling mediates host cell invasion by Trypanosoma cruzi
Embo J. 1998 Sep 01; 17(17): 4975-86.
