JCVI: About / Bios / Ewen F. Kirkness
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Ewen F. Kirkness, Ph.D.

Research Interests and Accomplishments

Dr. Ewen Kirkness is a Professor in the Genomic Medicine group at JCVI.  During his tenure at TIGR and JCVI, Dr Kirkness has acquired substantial experience in the production and analysis of genome-wide datasets, from early work on large-scale human EST production, to more recent analyses of RNA-seq datasets from tumor cells and lymphocytes. His management of diverse, large-scale sequencing projects has required the development and application of novel strategies for sequencing, assembly and analysis of sequence data. Dr. Kirkness managed NHGRI-funded projects at JCVI to sequence the genomes of hydra, louse and mosquito (including their bacterial endosymbionts). He also pioneered the use of survey sequencing to characterize large genomes, including those of dog and shark. He has applied DNA capture technologies, including hybrid selection, and incorporated these into the services provided by the NHLBI Resequencing Center at JCVI, which he also led until 2010. This Center sequenced more than 4,000 human DNA samples, detecting variant genotypes within targeted gene regions, and providing over 4 million genotype calls. His other ongoing research projects are focused on structural aspects of the human genome, including structural variation, long-range haplotyping, and allele-specific gene expression.

Dr. Kirkness received his B.Sc. (Biochemistry) from Heriot-Watt University, UK in 1982, and his Ph.D. (Biochemistry) from the University of Leeds, UK in 1986. Prior to joining TIGR, he conducted postdoctoral research in molecular neurobiology at the National Institutes of Health, USA.

Select Publications

Libonati MH, Dennis AF, et al.
Absence of Genetic Differences Among G10P[11] Rotaviruses Associated With Asymptomatic and Symptomatic Neonatal Infections in Vellore, India.

Journal of Virology. 2014 Jun 04;[more]

Bankamp B, Liu C, et al.
Wild-type Measles Viruses With Non-standard Genome Lengths.

PloS One. 2014 Apr 01; 9: e95470.[more]

Abernathy E, Chen MH, et al.
Analysis of Whole Genome Sequences of 16 Strains of Rubella Virus from the United States, 1961-2009.

Virology Journal. 2013 Sep 01; 10: 32.[more]

Tran TM, Samal B, et al.
Systems Immunology of Human Malaria.

Trends in parasitology. 2012 Jun 01; 28: 248-57.[more]

Ding ZL, Oskarsson M, et al.
Origins of Domestic Dog In Southern East Asia Is Supported by Analysis of Y-chromosome DNA.

Heredity. 2012 May 01; 108: 507-14.[more]

Gore, A., Li, Z., et al.
Somatic Coding Mutations In Human Induced Pluripotent Stem Cells

Nature. 2011 Mar 03; 471(7336): 63-7.[more]

Lawniczak, M. K., Emrich, S. J., et al.
Widespread Divergence Between Incipient Anopheles gambiae Species Revealed by Whole Genome Sequences

Science. 2010 Oct 22; 330(6003): 512-4.[more]

Kirkness, E. F., Haas, B. J., et al.
Genome Sequences of the Human Body Louse and Its Primary Endosymbiont Provide Insights Into the Permanent Parasitic Lifestyle

Proc Natl Acad Sci U S A. 2010 Jun 21; 107(27): 12168-73.[more]

Chapman, J. A., Kirkness, E. F., et al.
The Dynamic Genome of Hydra

Nature. 2010 Mar 14; 464(7288): 592-6.[more]