About
Biographies
Research Interests and Accomplishments
Gennady Denisov is a computational scientist at the J. Craig Venter Institute. His current research interests include computational analysis of genomic variations, metabolic reconstruction of microbial genomes, DNA sequencing quality values and base calling, and algorithmic software development for molecular biology. He contributed to the Human Genome Reference project, development of the JCVI Resequencing Pipeline, and modification of the Celera Assembler software to allow for variant detection.
Prior to joining the J. Craig Venter Institute, he worked for Paracel, a business unit of Celera Genomics based in Pasadena, CA. At Paracel, he was the key developer of TraceTuner, the DNA sequencing quality value and base calling software which was used by Celera in the sequencing the human genome. He also co-developed Paracel Genome Assembler and SeqScape, the SNP detection and genotyping software product by Applied Biosystems. Prior to joining Paracel, he conducted research on mathematical modeling at Cornell, SUNY at Stony Brook and M.I.T.
He received his Ph.D. degree in physics and mathematics from the Russian Academy of Sciences in Moscow.
Patents
Denisov, G, Ahehart, AB, et. al. System and method for improving the accuracy of DNA sequencing and error probability estimation through application of a mathematical model to the analysis of electropherograms. US patent number 6,681,186.
Select Publications
Denisov, G., Walenz, B., et al.
Consensus generation and variant detection by Celera Assembler
Bioinformatics. 2008 Apr 15; 24(8): 1035-40.
Levy, S., Sutton, G., et al.
The Diploid Genome Sequence of an Individual Human
PLoS Biol. 2007 Sep 04; 5(10): e254.
Denisov, G., Wanaski, S., et al.
Binding of basic peptides to membranes produces lateral domains enriched in the acidic lipids phosphatidylserine and phosphatidylinositol 4,5-bisphosphate: an electrostatic model and experimental results
Biophys J. 1998 Feb 01; 74(2): 731-44.
Ben-Tal, N., Honig, B., et al.
Binding of small basic peptides to membranes containing acidic lipids: theoretical models and experimental results
Biophys J. 1996 Aug 01; 71(2): 561-75.
Antonenko, Y. N., Denisov, G. A., et al.
Weak acid transport across bilayer lipid membrane in the presence of buffers. Theoretical and experimental pH profiles in the unstirred layers
Biophys J. 1993 Jun 01; 64(6): 1701-10.