About
Biographies
Research Interests and Accomplishments
Dr. John Glass is a Senior Scientist in the JCVI Synthetic Biology Group, where he directs the Mycoplasma Biology team. His expertise is in molecular biology, microbial pathogenesis, and microbial genomics. At the JCVI he led the mycoplasma minimal genome, and genome transplantation projects, and has been a key scientist in environmental genomics and viral metagenomics work.
Prior to joining the JCVI Dr. Glass spent five years in the Infectious Diseases Research Division of the pharmaceutical company Eli Lilly where he directed a Hepatitis C virology group and a microbial genomics group (1998-2003).
Glass earned his undergraduate (biology) and graduate degrees from the University of North Carolina at Chapel Hill. His Ph.D. work was on RNA virus genetics in the laboratory of Gail Wertz. He was on the faculty and did postdoctoral fellowships in the Microbiology Department of the University of Alabama at Birmingham in polio virology and mycoplasma pathogenesis (1990-1998). On sabbatical leave in Ellson Chen's lab at Applied Biosystems Inc.(1995-1997) he sequenced the genome of Ureaplasma parvum and began his study mycoplasma genomics.
Select Publications
Gibson, D. G., Glass, J. I., et al.
Creation of a Bacterial Cell Controlled by a Chemically Synthesized Genome
Science. 2010 Jul 02; 329(5987): 52-6.[more]
Gibson, D. G., Benders, G. A., et al.
Complete Chemical Synthesis, Assembly, and Cloning of a Mycoplasma genitalium Genome
Science. 2008 Jan 24; 319(5867): 1215-20.[more]
Williamson, S. J., Rusch, D. B., et al.
The Sorcerer II Global Ocean Sampling Expedition: Metagenomic Characterization of Viruses Within Aquatic Microbial Samples
PLoS ONE. 2008 Jan 23; 3(1): e1456.[more]
Lartigue, C., Glass, J. I., et al.
Genome Transplantation In Bacteria: Changing One Species to Another
Science. 2007 Aug 03; 317(5838): 632-8.[more]
Glass, J. I., Assad-Garcia, N., et al.
Essential Genes of a Minimal Bacterium
Proc Natl Acad Sci U S A. 2006 Jan 10; 103(2): 425-30.[more]
Larkin, J., Jin, L., et al.
Synergistic Antiviral Activity of Human Interferon Combinations In the Hepatitis C Virus Replicon System
J Interferon Cytokine Res. 2003 May 01; 23(5): 247-57.[more]
Glass, J. I., Lefkowitz, E. J., et al.
The Complete Sequence of the Mucosal Pathogen Ureaplasma urealyticum
Nature. 2000 Oct 12; 407(6805): 757-62.[more]