About
Biographies
Research Interests and Accomplishments
Jeffrey S. McLean is a Staff Scientist in the Microbial and Environmental Genomics Department at the JCVI in San Diego since 2007. He earned his degrees in Canada at the University of Toronto and University of Guelph. Prior to joining JCVI, he held a Scientist position at the Pacific Northwest National Laboratories where he served as an Investigator in Department of Energy (DOE) programs such as Genomes to Life, and the National Laboratory-funded Biomolecular Systems Initiative.
His research focus is primarily on the structure, diversity and function of microbial communities related to the human health, environmental remediation and bioenergy. He has extensive knowledge and experience with studying microbial biofilms which are the attached mode of growth for most bacteria.
He is currently active as a principal investigator on a DOE Environmental Remediation Sciences Program award to understand the metabolism and function of microbial biofilms in the subsurface and how they can be used to remediate contaminants at DOE sites. He is also funded through the NIH to understand biofilms related to oral caries disease using tools to link species with a metabolic function in this mixed community with techniques such as Stable Isotope Probing.
Select Publications
McLean JS, Lombardo MJ, et al.
Genome of the Pathogen Porphyromonas Gingivalis Recovered from a Biofilm In a Hospital Sink Using a High-throughput Single-cell Genomics Platform.
Genome Research. 2013 Apr 05;[more]
McLean JS, Fansler SJ, et al.
Identifying Low PH Active and Lactate-utilizing Taxa Within Oral Microbiome Communities from Healthy Children Using Stable Isotope Probing Techniques.
PloS one. 2012 Jul 01; 7: e32219.[more]
Allen, L. Z., Ishoey, T., et al.
Single Virus Genomics: a New Tool for Virus Discovery
PLoS ONE. 2011 Jan 01; 6(3): e17722.[more]
Renslow, R. S., Majors, P. D., et al.
In Situ Effective Diffusion Coefficient Profiles In Live Biofilms Using Pulsed-field Gradient Nuclear Magnetic Resonance
Biotechnol Bioeng. 2010 Aug 15; 106(6): 928-37.[more]
McLean JS, Wanger G, et al.
Quantification of Electron Transfer Rates to a Solid Phase Electron Acceptor Through the Stages of Biofilm Formation from Single Cells to Multicellular Communities.
Environmental science & technology. 2010 Apr 01; 44(7): 2721-7.[more]
McLean, J. S., Majors, P. D., et al.
Investigations of Structure and Metabolism Within Shewanella oneidensis MR-1 Biofilms
J Microbiol Methods. 2008 Jul 01; 74(1): 47-56.[more]
McLean, J. S., Pinchuk, G. E., et al.
Oxygen-dependent Autoaggregation In Shewanella oneidensis MR-1
Environ Microbiol. 2008 Apr 09; 10(7): 1861-76.[more]
McLean, J. S., Ona, O. N., et al.
Correlated Biofilm Imaging, Transport and Metabolism Measurements Via Combined Nuclear Magnetic Resonance and Confocal Microscopy
Isme J. 2008 Feb 01; 2(2): 121-31.[more]
Marshall, M. J., Beliaev, A. S., et al.
C-Type Cytochrome-dependent Formation of U(IV) Nanoparticles by Shewanella oneidensis
PLoS Biol. 2006 Sep 01; 4(9): e268.[more]
Gorby, Y. A., Yanina, S., et al.
Electrically Conductive Bacterial Nanowires Produced by Shewanella oneidensis Strain MR-1 and Other Microorganisms
Proc Natl Acad Sci U S A. 2006 Jul 25; 103(30): 11358-63.[more]