JCVI: About / Bios / Jeffrey S. McLean
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Jeffrey S. McLean
Assistant Professor

Research Interests and Accomplishments

Dr. McLean’s research interest over the last 13 years at the Pacific Northwest National Laboratory and the J. Craig Venter Institute has been primarily devoted to understanding microbial interactions within biofilm communities. Currently, he is leading projects focused on oral diseases with grants from NIH (NIDCR and NIGMS). Within these projects, the overall goal is to gain an understanding for the molecular basis of oral bacterial interactions and further develop innovative methodologies, tools and integrated genomic based approaches (systems approaches) to ultimately translate this fundamental knowledge to the overall benefit of human health.

Select Publications

McLean JS, Lombardo MJ, et al.
Candidate Phylum TM6 Genome Recovered from a Hospital Sink Biofilm Provides Genomic Insights Into This Uncultivated Phylum.

Proceedings of the National Academy of Sciences of the United States of America. 2013 Jun 10;[more]

McLean JS, Lombardo MJ, et al.
Genome of the Pathogen Porphyromonas Gingivalis Recovered from a Biofilm In a Hospital Sink Using a High-throughput Single-cell Genomics Platform.

Genome Research. 2013 Apr 05;[more]

McLean JS, Fansler SJ, et al.
Identifying Low PH Active and Lactate-utilizing Taxa Within Oral Microbiome Communities from Healthy Children Using Stable Isotope Probing Techniques.

PloS one. 2012 Jul 01; 7: e32219.[more]

Allen, L. Z., Ishoey, T., et al.
Single Virus Genomics: a New Tool for Virus Discovery

PLoS ONE. 2011 Jan 01; 6(3): e17722.[more]

Renslow, R. S., Majors, P. D., et al.
In Situ Effective Diffusion Coefficient Profiles In Live Biofilms Using Pulsed-field Gradient Nuclear Magnetic Resonance

Biotechnol Bioeng. 2010 Aug 15; 106(6): 928-37.[more]

McLean JS, Wanger G, et al.
Quantification of Electron Transfer Rates to a Solid Phase Electron Acceptor Through the Stages of Biofilm Formation from Single Cells to Multicellular Communities.

Environmental science & technology. 2010 Apr 01; 44(7): 2721-7.[more]

McLean, J. S., Majors, P. D., et al.
Investigations of Structure and Metabolism Within Shewanella oneidensis MR-1 Biofilms

J Microbiol Methods. 2008 Jul 01; 74(1): 47-56.[more]

McLean, J. S., Pinchuk, G. E., et al.
Oxygen-dependent Autoaggregation In Shewanella oneidensis MR-1

Environ Microbiol. 2008 Apr 09; 10(7): 1861-76.[more]

McLean, J. S., Ona, O. N., et al.
Correlated Biofilm Imaging, Transport and Metabolism Measurements Via Combined Nuclear Magnetic Resonance and Confocal Microscopy

Isme J. 2008 Feb 01; 2(2): 121-31.[more]

Marshall, M. J., Beliaev, A. S., et al.
C-Type Cytochrome-dependent Formation of U(IV) Nanoparticles by Shewanella oneidensis

PLoS Biol. 2006 Sep 01; 4(9): e268.[more]

Gorby, Y. A., Yanina, S., et al.
Electrically Conductive Bacterial Nanowires Produced by Shewanella oneidensis Strain MR-1 and Other Microorganisms

Proc Natl Acad Sci U S A. 2006 Jul 25; 103(30): 11358-63.[more]