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Biographies

Liliana Losada, Ph.D.
Assistant Professor

Research Interests and Accomplishments

Dr. Liliana Losada is an Infectious Disease Investigator at the J. Craig Venter Institute (JCVI). Dr. Losada received her Ph.D. studying the role of type III secretion systems in host-pathogen interactions using the plant pathogenic bacterium Pseudomonas syringae as a model system. Since then, she has applied whole-genome technologies, including genomics and transcritpomics to characterize the evolution and molecular interactions of Gram-negative pathogens with their host. Her research has focused primarily on the respiratory pathogens including Burkholderia cenocepacia complex, Burkholderia pseudomallei, Burkolderia mallei and Bordetella pertussis. In addition to bacterial pathogens, Dr. Losada's research expanded to include the fungal respiratory pathogens Aspergillus fumigatus and Cryptococcus gattii, especially in elucidating the transcriptional mechanisms that lead to invasive disease or fungal clearance. As a natural extension of her research focus on respiratory pathogens, Dr. Losada is currently investigating the role of the nasopharyngeal microbiome in establishment and prevention of pneumonia caused by Streptococcus pneumoniae, and how these respond to vaccine pressure.

Dr. Losada received her doctoral degree in Molecular and Cell Biology from the University of Maryland at College Park in 2004. After graduation, she was awarded a Clare Boothe Luce Fellowship from Trinity (Washington) University, where she was an Assistant Professor of Biology while continuing her research in collaboration with scientists at TIGR/JCVI. She joined JCVI as a full time researcher and Assistant Professor in 2010.

Select Publications

Losada L, Barker BM, et al.
Large-Scale Transcriptional Response to Hypoxia in Aspergillus fumigatus Observed Using RNAseq Identifies a Novel Hypoxia Regulated NcRNA.

Mycopathologia. 2014 Dec 01; 178: 331-9.[more]

Harvill ET, Goodfield LL, et al.
Genome Sequences of Nine Bordetella Holmesii Strains Isolated in the United States.

Genome Announcements. 2014 Jul 01; 2[more]

Harvill ET, Goodfield LL, et al.
Genome Sequences of 28 Bordetella pertussis U.S. Outbreak Strains Dating from 2010 to 2012.

Genome Announcements. 2013 Feb 01; 1[more]

Vipond J, Kane J, et al.
Sequence Determination of Burkholderia pseudomallei Strain NCTC 13392 Colony Morphology Variants.

Genome Announcements. 2013 Feb 01; 1[more]

Varga JJ, Losada L, et al.
Draft Genome Sequences of Burkholderia cenocepacia ET12 Lineage Strains K56-2 and BC7.

Genome Announcements. 2013 Feb 01; 1[more]

Varga JJ, Losada L, et al.
Draft Genome Sequence Determination for Cystic Fibrosis and Chronic Granulomatous Disease Burkholderia multivorans Isolates.

Journal of bacteriology. 2012 Nov 01; 194: 6356-7.[more]

Rivera ZS, Losada L, et al.
Back to the Future for Dermatophyte Genomics.

MBio. 2012 Apr 01; 3[more]

Losada, L., Varga, J. J., et al.
Genome Sequencing and Analysis of Yersina pestis KIM D27, an Avirulent Strain Exempt from Select Agent Regulation.

PloS one. 2011 Mar 01; 6(4): e19054.[more]

Sugui JA, Losada L, et al.
Identification and Characterization of an Aspergillus fumigatus "supermater" Pair.

mBio. 2011 Mar 01; 2[more]

Ronning, C. M., Losada, L., et al.
Genetic and Phenotypic Diversity In Burkholderia: Contributions by Prophage and Phage-like Elements

BMC Microbiol. 2010 Jul 28; 10(1): 202.[more]

Losada, L., Ronning, C. M., et al.
Continuing Evolution of Burkholderia mallei Through Genome Reduction and Large-Scale Rearrangements

Genome Biol Evol. 2010 Mar 01; 2010: 102-16.[more]

Nandi, T., Ong, C., et al.
A Genomic Survey of Positive Selection In Burkholderia pseudomallei Provides Insights Into the Evolution of Accidental Virulence

PLoS Pathog. 2010 Feb 15; 6(4): e1000845.[more]

Losada, L., Ajayi, O., et al.
Effect of Competition on the Production and Activity of Secondary Metabolites In Aspergillus Species

Med Mycol. 2009 Mar 02;: 1-9.[more]

Losada LC, Hutcheson SW
Type III Secretion Chaperones of Pseudomonas Syringae Protect Effectors from Lon-associated Degradation.

Molecular microbiology. 2005 Feb 01; 55: 941-53.[more]