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About

Biographies

Mark Adams, Ph.D.
Scientific Director
Professor

Research Interests and Accomplishments

Dr. Mark Adams is Scientific Director for the J. Craig Venter Institute. Dr. Adams comes from a rich background including industry, government, academic, and nonprofit settings. Throughout he has focused on applying leading edge genomic and bioinformatic approaches to a variety of research problems in biology. Trained as a microbiologist and biochemist, he developed a strong interest in bioinformatics in the early 1990s. Through 13 years working at NIH, The Institute for Genomic Research (TIGR), and Celera Genomics, he was responsible for applying new sequencing technologies and analytical approaches to sequencing of ESTs, microbial genomes, and ultimately the human genome.

As one of the founding scientists at TIGR, Dr. Adams established and managed the large-scale DNA sequencing facility. The initial work focused on developing a large collection of ESTs from several hundred cDNA libraries. He also contributed extensively to determining the first genome sequence of a free-living organism, Haemophilus influenzae, among other microbial genomes. In 1998, Dr. Adams co-founded Celera Genomics, where he was responsible for the DNA sequencing and genome annotation groups. He directed the Drosophila, human, and mouse genome sequencing projects and re-sequencing of exons and regulatory regions of all human genes to identify novel functional SNPs.

Following his work at Celera Genomics, in 2003 Dr. Adams went to Case Western Reserve (CWRU) as an Associate Professor in the Department of Genetics where his focus shifted towards leveraging newly available genome information and technology driven by investigation of fundamental biological problems. At CWRU, he developed a research program in the evolution and mechanisms of antibiotic resistance in the nosocomial pathogen Acinetobacter baumannii. He also served as Director of the Genomics Core facility where he assisted a large number of investigators with applying current genotyping, expression, and sequencing technologies to their particular research areas.

Dr. Adams received a B.A. in Chemistry from Warren Wilson College in Swannanoa, NC in 1984. He received his Ph.D. in Biological Chemistry from the University of Michigan in 1990. His dissertation work involved characterization of the genes involved in branched-chain amino acid transport in Escherichia coli.

Select Publications

Santos-Cortez RL, Lee K, et al.
Mutations in KARS, Encoding Lysyl-tRNA Synthetase, Cause Autosomal-Recessive Nonsyndromic Hearing Impairment DFNB89.

American Journal of Human Genetics. 2013 Jun 12;[more]

Lin L, Tan B, et al.
Inhibition of LpxC Protects Mice from Resistant Acinetobacter Baumannii by Modulating Inflammation and Enhancing Phagocytosis.

MBio. 2012 Sep 01; 3[more]

Zentner, G. E., Saiakhova, A., et al.
Integrative Genomic Analysis of Human Ribosomal DNA

Nucleic Acids Res. 2011 Jul 01; 39(12): 4949-60.[more]

Baker, A. R., Zalwango, S., et al.
Genetic Susceptibility to tuberculosis Associated With Cathepsin Z Haplotype In a Ugandan Household Contact Study

Hum Immunol. 2011 May 01; 72(5): 426-30.[more]

Ramirez, M. S., Adams, M. D., et al.
Genomic Analysis of Acinetobacter Baumannii A118 by Comparison of Optical Maps: Identification of Structures Related to Its Susceptibility Phenotype

Antimicrob Agents Chemother. 2011 Apr 01; 55(4): 1520-6.[more]

Larkin, E. K., Patel, S. R., et al.
A Candidate Gene Study of Obstructive Sleep Apnea In European Americans and African Americans

Am J Respir Crit Care Med. 2010 Oct 01; 182(7): 947-53.[more]

Adams, M. D., Chan, E. R., et al.
Genomewide Analysis of Divergence of Antibiotic Resistance Determinants In Closely Related Isolates of Acinetobacter Baumannii

Antimicrob Agents Chemother. 2010 Sep 01; 54(9): 3569-77.[more]

Perez, F., Endimiani, A., et al.
Carbapenem-resistant Acinetobacter Baumannii and Klebsiella pneumoniae Across a Hospital System: Impact of Post-acute Care Facilities on Dissemination

J Antimicrob Chemother. 2010 Aug 01; 65(8): 1807-18.[more]

Gray-McGuire, C., Guda, K., et al.
Confirmation of Linkage to and Localization of Familial Colon Cancer Risk Haplotype on chromosome 9q22

Cancer Res. 2010 Jul 01; 70(13): 5409-18.[more]

Adams, M. D., Nickel, G. C., et al.
Resistance to Colistin In Acinetobacter Baumannii Associated With Mutations In the PmrAB Two-component System

Antimicrob Agents Chemother. 2009 Sep 01; 53(9): 3628-34.[more]

Chan, E. R., Lavender, H., et al.
An ENU-induced Recessive Mutation In Mpl Leads to Thrombocytopenia With Overdominance

Exp Hematol. 2009 Feb 01; 37(2): 276-84.[more]

Neilson, D. E., Adams, M. D., et al.
Infection-triggered Familial or Recurrent Cases of Acute Necrotizing Encephalopathy Caused by Mutations In a Component of the Nuclear Pore, RANBP2

Am J Hum Genet. 2009 Jan 01; 84(1): 44-51.[more]

Adams, M. D., Goglin, K., et al.
Comparative Genome Sequence Analysis of Multidrug-resistant Acinetobacter Baumannii

J Bacteriol. 2008 Dec 01; 190(24): 8053-64.[more]

Venter, J. C., Adams, M. D., et al.
The Sequence of the Human Genome

Science. 2001 Feb 16; 291(5507): 1304-51.[more]

Adams, M. D., Celniker, S. E., et al.
The Genome Sequence of Drosophila melanogaster

Science. 2000 Mar 24; 287(5461): 2185-95.[more]