About
Biographies
Research Interests and Accomplishments
Mikkel Algire is an Assistant Professor in the Synthetic Biology and Bioenergy Group at the J. Craig Venter Institute (JCVI). Mikkel is part of the team developing the technologies to produce a synthetic cell. His research interests include developing de novo gene and genome synthesis techniques and genome manipulation technologies and applying them to engineering bacterial metabolism.
Prior to joining JCVI, Mikkel received his Ph.D. degree in Biophysics from the Johns Hopkins School of Medicine where he investigated the kinetics and thermodynamics of eukaryotic translation initiation using an in vitro S. cerevisiae translation system. Mikkel received his B.S. degree in Biochemistry and Molecular Biology from the University of Florida. He joined JCVI in 2006 as a Post-Doc.
Publications
Lartigue, C., Vashee, S., et al.
Creating Bacterial Strains from Genomes That Have Been Cloned and Engineered in Yeast
Science. 2009 Aug 20;[more]
Gibson, D. G., Benders, G. A., et al.
One-step assembly in yeast of 25 overlapping DNA fragments to form a complete synthetic Mycoplasma genitalium genome
Proc Natl Acad Sci U S A. 2008 Dec 23; 105(51): 20404-9.[more]
Gibson, D. G., Benders, G. A., et al.
Complete Chemical Synthesis, Assembly, and Cloning of a Mycoplasma genitalium Genome
Science. 2008 Jan 24; 319(5867): 1215-20.[more]
Algire, M. A., Maag, D., et al.
Pi release from eIF2, not GTP hydrolysis, is the step controlled by start-site selection during eukaryotic translation initiation
Mol Cell. 2005 Oct 28; 20(2): 251-62.[more]