
About
Biographies
Research Interests and Accomplishments
Dr. Basu started his independent research work in bioinformatics while carrying out his Ph.D. work in Center for Cellular and Molecular Biology (CCMB), India. He is an expert in the area of web programming and one of the first to apply Scalable Vector Graphics (SVG) in Bioinformatics. He wrote several software, some of which are: SeWeR, an integrated platform for sequence analysis over the Internet; Savvy, a plasmid-drawing software that generates plasmid maps in SVG; Pastel, a library to generate SVG; BioSVG, a library to generate SVG for biological data; and many more. He did his post-doctoral work in Eugene Koonin's lab at National Center for Biotechnology Information (NCBI), where his work mainly focused on intron evolution and evolution of protein domain-architecture.
At JCVI, Dr. Basu carries out his work in evolution of genome-architecture and on writing new computational tools leveraging the latest web technologies. He also contributes to several ongoing projects at JCVI, including TIGRFAM, protein family reconstruction, phylogenetic profile comparison, and creation of pangenome.
Select Publications
Basu, M. K., Selengut, J. D., et al.
ProPhylo: partial phylogenetic profiling to guide protein family construction and assignment of biological process
BMC Bioinformatics. 2011 Dec 01; 12: 434.[more]
Colbourne, J. K., Pfrender, M. E., et al.
The ecoresponsive genome of Daphnia pulex
Science. 2011 Feb 04; 331(6017): 555-61.[more]
Basu, M. K., Poliakov, E., et al.
Domain mobility in proteins: functional and evolutionary implications
Brief Bioinform. 2009 May 01; 10(3): 205-16.[more]
Basu, M. K., Rogozin, I. B., et al.
Primordial spliceosomal introns were probably U2-type
Trends Genet. 2008 Nov 01; 24(11): 525-8.[more]
Basu, M. K., Carmel, L., et al.
Evolution of protein domain promiscuity in eukaryotes
Genome Res. 2008 Mar 01; 18(3): 449-61.[more]
Basu, M. K., Makalowski, W., et al.
U12 intron positions are more strongly conserved between animals and plants than U2 intron positions
Biol Direct. 2008 Jan 01; 3: 19.[more]
Basu, M. K., Rogozin, I. B., et al.
Evolutionary dynamics of introns in plastid-derived genes in plants: saturation nearly reached but slow intron gain continues
Mol Biol Evol. 2008 Jan 01; 25(1): 111-9.[more]
