About
Biographies
Research Interests and Accomplishments
Dr. Pauline Ng is a Senior Scientist in the Department of Genomic Medicine at the J. Craig Venter Institute (JCVI). Her main interests include understanding human disease and how human variation relates to phenotype.
Prior to joining JCVI, Dr. Ng was a Bioinformatics Senior Scientist at Illumina, Inc. where she developed Illumina’s whole-genome genotyping panels. In order to optimize the genotyping panels, a tag SNP selection strategy was employed. These panels are currently used in genome-wide association studies and have detected disease regions in diseases such as type 2 diabetes, prostate cancer, and Crohn’s.
Prior to Illumina, Dr. Ng developed the prediction algorithm SIFT at Fred Hutchinson Cancer Research Center. SIFT predicts if an amino acid substitution affects protein function and can be applied to nonsynonymous polymorphisms. This algorithm is used world-wide and is popular among geneticists and epidemiologists. Dr. Ng received her bachelor's degree in biology from Caltech and Ph.D. in bioengineering from University of Washington.
Select Publications
Eberle, M. A., Ng, P. C., et al.
Power to detect risk alleles using genome-wide tag SNP panels
PLoS Genet. 2007 Oct 01; 3(10): 1827-37.
Levy, S., Sutton, G., et al.
The Diploid Genome Sequence of an Individual Human
PLoS Biol. 2007 Sep 04; 5(10): e254.
Ng, P. C., Henikoff, S.
Predicting the effects of amino acid substitutions on protein function
Annu Rev Genomics Hum Genet. 2006 Sep 01; 7: 61-80.
Gunderson, K. L., Kuhn, K. M., et al.
Whole-genome genotyping of haplotype tag single nucleotide polymorphisms
Pharmacogenomics. 2006 Jun 01; 7(4): 641-8.
Ng, P. C., Henikoff, S.
Accounting for human polymorphisms predicted to affect protein function
Genome Res. 2002 Mar 01; 12(3): 436-46.