JCVI: About / Bios / Robert Coyne
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Robert S. Coyne, Ph.D.
Associate Professor

Research Interests and Accomplishments

Bob Coyne joined TIGR in 2005 to work on the genome sequencing project of the ciliated protozoan Tetrahymena thermophila. His research interests focus on the elaborate genome rearrangements that occur in ciliates during formation of the somatic nucleus. He is currently developing forward and reverse genetic tools to facilitate the use of Tetrahymena as a model organism for molecular and cellular biology. He has also led the project to sequence and annotate the genome of a related ciliate, Ichthyophthirius multifiliis or "Ich", a parasite of freshwater fish that is a major pest of the aquaculture industry.

Bob received his B.S. from Allegheny College and Ph.D. from Harvard University. He did post-doctoral research at the Massachusetts General Hospital and Fred Hutchinson Cancer Research Center. He held faculty or research faculty positions at Colgate University, Cornell University and the University of Virginia.

Select Publications

Sun, H. Y., Noe, J., et al.
Endosymbiotic Bacteria In the Parasitic Ciliate Ichthyophthirius multifiliis

Appl Environ Microbiol. 2009 Dec 01; 75(23): 7445-52.[more]

Coyne, R. S., Thiagarajan, M., et al.
Refined Annotation and Assembly of the Tetrahymena thermophila Genome Sequence Through EST Analysis, Comparative Genomic Hybridization, and Targeted Gap Closure

BMC Genomics. 2008 Sep 01; 9: 562.[more]

Yao, M. C., Yao, C. H., et al.
Identification of Novel Chromatin-associated Proteins Involved In Programmed Genome Rearrangements In Tetrahymena

J Cell Sci. 2007 Jun 15; 120(0): 1978-89.[more]

Cervantes, M. D., Coyne, R. S., et al.
The Condensin Complex Is Essential for Amitotic Segregation of Bulk Chromosomes, but Not Nucleoli, In the Ciliate Tetrahymena thermophila

Mol Cell Biol. 2006 Jun 01; 26(12): 4690-700.[more]

Taverna, S. D., Coyne, R. S., et al.
Methylation of Histone H3 at Lysine 9 Targets Programmed DNA Elimination In Tetrahymena

Cell. 2002 Sep 20; 110(6): 701-11.[more]

Coyne, R. S., Nikiforov, M. A., et al.
Parental Expression of the Chromodomain Protein Pdd1p Is Required for Completion of Programmed DNA Elimination and Nuclear Differentiation

Mol Cell. 1999 Nov 01; 4(5): 865-72.[more]

Coyne, R. S., Yao, M. C.
Evolutionary Conservation of Sequences Directing chromosome Breakage and RDNA Palindrome Formation In Tetrahymenine Ciliates

Genetics. 1996 Dec 01; 144(4): 1479-87.[more]

Madireddi, M. T., Coyne, R. S., et al.
Pdd1p, a Novel Chromodomain-containing Protein, Links Heterochromatin Assembly and DNA Elimination In Tetrahymena

Cell. 1996 Oct 04; 87(1): 75-84.[more]

Coyne, R. S., Chalker, D. L., et al.
Genome Downsizing During Ciliate Development: Nuclear Division of Labor Through chromosome Restructuring

Annu Rev Genet. 1996 Mar 01; 30: 557-78.[more]