About
Biographies
Research Interests and Accomplishments
Dr. Fleischmann is currently a faculty Investigator at the JCVI and the Administrative Director of the Pathogen Functional Genomics Resource Center. He has been at JCVI since 1992, originally joining its legacy organization, TIGR (The Institute for Genome Research). As one of the founding members of the TIGR faculty, Dr. Fleischmann was lead scientist in the ground breaking project to complete the sequence, annotation, and publication of the first complete genome sequence from H. influenzae. This shotgun sequencing approach to large scale genome sequencing has become the cornerstone of essentially all complete genome sequencing projects to follow, from virus to man.
Dr. Fleischmann has led the sequencing efforts of several Mycobacterial and dental pathogens. He completed the sequence of the first clinical M. tuberculosis isolate and published the detailed comparative analyses of the laboratory and clinical strains. Subsequent work in comparative genomics has focused on the identification of relevant SNP marker for understanding the genomic population dynamics of M. tuberculosis and closely related strains.
Select Publications
Alland, D., Lacher, D. W., et al.
The role of large sequence polymorphisms in generating genomic diversity in clinical isolates of Mycobacterium tuberculosis and their utility in phylogenetic analysis
J Clin Microbiol. 2006 Nov 01;[more]
Filliol, I., Motiwala, A. S., et al.
Global phylogeny of Mycobacterium tuberculosis based on single nucleotide polymorphism (SNP) analysis: insights into tuberculosis evolution, phylogenetic accuracy of other DNA fingerprinting systems, and recommendations for a minimal standard SNP set
J Bacteriol. 2006 Jan 01; 188(2): 759-72.[more]
Alland, D., Whittam, T. S., et al.
Modeling Bacterial Evolution with Comparative-Genome-Based Marker Systems: Application to Mycobacterium tuberculosis Evolution and Pathogenesis
J Bacteriol. 2003 Jun 01; 185(11): 3392-3399.[more]
Fleischmann, R. D., Alland, D., et al.
Whole-genome comparison of Mycobacterium tuberculosis clinical and laboratory strains
J Bacteriol. 2002 Oct 01; 184(19): 5479-90.[more]
Plikaytis, B. B., Kurepina, N., et al.
Multiplex PCR assay to aid in the identification of the highly transmissible Mycobacterium tuberculosis strain CDC1551
Tuber Lung Dis. 1999 Sep 01; 79(5): 273-8.[more]
Fleischmann, R. D., Adams, M. D., et al.
Whole-genome random sequencing and assembly of Haemophilus influenzae Rd
Science. 1995 Jul 28; 269(5223): 496-512.[more]
Smith, H. O., Tomb, J. F., et al.
Frequency and distribution of DNA uptake signal sequences in the Haemophilus influenzae Rd genome
Science. 1995 Jul 28; 269(5223): 538-40.[more]