JCVI: About / Bios / Rembert Pieper
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Rembert Pieper, Ph.D.
Campus Director, Rockville

Research Focus

Protein biomarker discovery for human disease diagnosis and progression

  • Emphasis on protein biomarkers for diabetes, diseases of the kidneys and the urogenital tract

Characterization of host-pathogen interactions using proteomics and other ‘omics technologies

  • Emphasis on urogenital tract and gastrointestinal infectious diseases

Analysis of complex microbiomes using proteomics and other ‘omics technologies

  • Emphasis on host-pathogen-commensal relationships in the urogenital tract

Development of new methods and technology transfer for protein-based clinical diagnostics

  • Emphasis on increasing efficiency of urine and plasma protein and whole proteome analysis

Education and Training

  • Postdoctoral Fellow Molecular Biology and Biochemistry, Stanford University, Stanford, California
  • Ph.D. Molecular Biology and Biochemistry, Technical University, Berlin, Germany
  • B.S./M.S. equivalent Pharmacy, Philipps University, Marburg, Germany

Work Experience

  • J. Craig Venter Institute, 2009-Present, Associate Professor, Genomic Medicine and Infectious Diseases
  • J. Craig Venter Institute, 2003-2010, Associate Director, Pathogen Funct. Genomics Resource Center
  • Large Scale Biology Corporation, 1999-2003, Associate Director (2001) and Staff Scientist, Protein Chemistry
  • National Cancer Institute, 1996-1998, Research Fellow, Protein Chemistry and Tumor Immunology

Patents (since 2010)

  • U.S. Patent #7,342,089 (issued 1/5/10): Immunoaffinity-Based Subtraction Method
  • U.S. Patent, No. US20130178377 (published 7/2013): Metaproteomic method for diagnosis of bacteriuria, urogenital tract and kidney infections from urinary pellet samples 

Select Publications

Yu Y, Pieper R
Urine Sample Preparation in 96-well Filter Plates to Characterize Inflammatory and infectious Diseases of the Urinary Tract.

Advances in Experimental Medicine and Biology. 2015 Apr 01; 845: 77-87.[more]

Yu Y, Pieper R
Urinary Pellet Sample Preparation for Shotgun Proteomic Analysis of Microbial Infection and Host-pathogen Interactions.

Methods in Molecular Biology (Clifton, N.J.). 2015 Apr 01; 1295: 65-74.[more]

Memisevic V, Zavaljevski N, et al.
Mining Host-pathogen Protein Interactions to Characterize Burkholderia mallei Infectivity Mechanisms.

PLoS Computational Biology. 2015 Mar 01; 11: e1004088.[more]

Suh MJ, Kuntumalla S, et al.
Proteomes of Pathogenic Escherichia Coli/Shigella Group Surveyed in Their Host Environments.

Expert Review of Proteomics. 2014 Oct 01; 11: 593-609.[more]

Yu Y, Suh MJ, et al.
Urine Sample Preparation in 96-well Filter Plates for Quantitative Clinical Proteomics.

Analytical Chemistry. 2014 Jun 03; 86: 5470-7.[more]

Pieper R, Huang ST, et al.
Proteomics and Metaproteomics

Encyclopedia of Metagenomics (SPi Global). 2014 Apr 08;: 1-11.[more]

Rajagopala SV, Sikorski P, et al.
The Binary Protein-protein Interaction Landscape of Escherichia Coli.

Nature Biotechnology. 2014 Mar 01; 32: 285-90.[more]

Memisevic V, Zavaljevski N, et al.
Novel Burkholderia mallei Virulence Factors Linked to Specific Host-Pathogen Protein Interactions.

Molecular & Cellular Proteomics : MCP. 2013 Jun 24;[more]

Fouts DE, Pieper R, et al.
Integrated Next-generation Sequencing of 16S RDNA and Metaproteomics Differentiate the Healthy Urine Microbiome from Asymptomatic Bacteriuria in Neuropathic Bladder Associated With Spinal Cord Injury.

Journal of Translational Medicine. 2012 Nov 01; 10: 174.[more]