JCVI: About / Bios / Reed Shabman
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Reed Shabman, Ph.D.
Assistant Professor

Research Interests and Accomplishments

Dr. Reed Shabman is an Infectious Disease Investigator at the J. Craig Venter Institute (JCVI).  The goal of Dr. Shabman’s current research is to understand the interplay between zoonotic viruses and their hosts.  Specific areas of interest include defining the host immune response following infection, identifying unique mechanisms of viral gene expression, and discovering novel viral innate immune evasion strategies.  Knowledge within these areas will aid in the development of successful vaccines and therapeutics to counteract virus infection.  His most recent work is focused on the highly virulent filoviruses (Ebola and Marburg virus), which are classified as NIAID Category A Priority Pathogens and CDC Bioterrorism Agents.  To accomplish these research goals, Dr. Shabman is actively integrating next generation sequencing technologies at JCVI. 

Dr. Shabman received his Ph.D. in 2008 from the Department of Microbiology and Immunology at the University of North Carolina at Chapel Hill (UNC-CH) under the direction of Dr. Mark Heise.  At UNC-CH he studied Alphaviruses, mosquito-borne viruses that cause significant human disease.  He then completed his postdoctoral studies in the lab of Dr. Christopher Basler at the Icahn School of Medicine at Mount Sinai in New York before joining JCVI.  His research interests at Mount Sinai included mechanisms of filovirus gene expression and their immune evasion strategies.

Select Publications

Shabman RS, Shrivastava S, et al.
Isolation and Characterization of a Novel Gammaherpesvirus from a Microbat Cell Line.

MSphere. 2016 Jan 01; 1[more]

Shabman RS, Jabado OJ, et al.
Deep Sequencing Identifies Noncanonical Editing of Ebola and Marburg Virus RNAs in Infected Cells.

MBio. 2014 Nov 01; 5[more]

Binning JM, Wang T, et al.
Development of RNA Aptamers Targeting Ebola Virus VP35.

Biochemistry. 2013 Nov 26; 52: 8406-19.[more]

Martinez O, Johnson JC, et al.
Ebola Virus Exploits a Monocyte Differentiation Program to Promote Its Entry.

Journal of Virology. 2013 Apr 01; 87: 3801-14.[more]

Shabman RS, Hoenen T, et al.
An Upstream Open Reading Frame Modulates Ebola Virus Polymerase Translation and Virus Replication.

PLoS Pathogens. 2013 Jan 01; 9: e1003147.[more]

Ramanan P, Edwards MR, et al.
Structural Basis for Marburg Virus VP35-mediated Immune Evasion Mechanisms.

Proceedings of the National Academy of Sciences of the United States of America. 2012 Dec 11; 109: 20661-6.[more]

Aguirre S, Maestre AM, et al.
DENV Inhibits Type I IFN Production in Infected Cells by Cleaving Human STING.

PLoS Pathogens. 2012 Dec 01; 8: e1002934.[more]

Hoenen T, Shabman RS, et al.
Inclusion Bodies Are a Site of Ebolavirus Replication.

Journal of Virology. 2012 Nov 01; 86: 11779-88.[more]

Shabman RS, Leung DW, et al.
DRBP76 Associates With Ebola Virus VP35 and Suppresses Viral Polymerase Function.

The Journal of infectious Diseases. 2011 Nov 01; 204: S911-8.[more]

Shabman RS, Gulcicek EE, et al.
The Ebola Virus VP24 Protein Prevents HnRNP C1/C2 Binding to Karyopherin ?1 and Partially Alters Its Nuclear Import.

The Journal of infectious Diseases. 2011 Nov 01; 204: S904-10.[more]

Ramanan P, Shabman RS, et al.
Filoviral Immune Evasion Mechanisms.

Viruses. 2011 Sep 01; 3: 1634-49.[more]

Prins KC, Binning JM, et al.
Basic Residues Within the Ebolavirus VP35 Protein Are Required for Its Viral Polymerase Cofactor Function.

Journal of Virology. 2010 Oct 01; 84: 10581-91.[more]

Leung DW, Shabman RS, et al.
Structural and Functional Characterization of Reston Ebola Virus VP35 Interferon Inhibitory Domain.

Journal of Molecular Biology. 2010 Jun 11; 399: 347-57.[more]

Cruz CC, Suthar MS, et al.
Modulation of Type I IFN Induction by a Virulence Determinant Within the Alphavirus NsP1 Protein.

Virology. 2010 Mar 30; 399: 1-10.[more]

Shabman RS, Rogers KM, et al.
Ross River Virus Envelope Glycans Contribute to Type I Interferon Production in Myeloid Dendritic Cells.

Journal of Virology. 2008 Dec 01; 82: 12374-83.[more]

Ljungberg K, Whitmore AC, et al.
Increased Immunogenicity of a DNA-launched Venezuelan Equine Encephalitis Virus-based Replicon DNA Vaccine.

Journal of Virology. 2007 Dec 01; 81: 13412-23.[more]

Shabman RS, Morrison TE, et al.
Differential Induction of Type I Interferon Responses in Myeloid Dendritic Cells by Mosquito and Mammalian-cell-derived Alphaviruses.

Journal of Virology. 2007 Jan 01; 81: 237-47.[more]

Morrison TE, Whitmore AC, et al.
Characterization of Ross River Virus Tropism and Virus-induced Inflammation in a Mouse Model of Viral Arthritis and Myositis.

Journal of Virology. 2006 Jan 01; 80: 737-49.[more]

Suthar MS, Shabman R, et al.
Identification of Adult Mouse Neurovirulence Determinants of the Sindbis Virus Strain AR86.

Journal of Virology. 2005 Apr 01; 79: 4219-28.[more]