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About

Biographies

Suman Das, Ph.D.
Associate Professor

Research Interests and Accomplishments

Dr. Suman Ranjan Das is an Infectious Disease Investigator at the J. Craig Venter Institute (JCVI). Dr. Das received his Ph.D. in virology in 2005 studying HIV-1 subtype C at the International Center for Genetic Engineering and Biotechnology (ICGEB), New Delhi, India. He did his postdoctoral fellowship in the Laboratory of Viral Diseases at NIAID, NIH as a Fogarty International fellow where his research was focused on understanding antigenic evolution of influenza A virus.  Prior to joining JCVI, he worked at Emory Vaccine Center, Atlanta to study human B-cell response to influenza infection and vaccination.

Seasonal influenza A virus is one of the major causes of human influenza related morbidity and mortality worldwide, causing about 300,000-500,000 deaths every year. The current research focus of Dr. Das is to combat seasonal influenza by developing novel vaccine candidates and therapeutics using various, basic virology and immunology techniques and bioinformatics tools.  Employing a two-pronged research approach, he is developing in vitro and in vivo models to understand the underlying mechanisms that contribute to antigenic evolution of influenza virus to escape the host immune response. By combining bioinformatics and mathematical tools, he is evaluating the experimental data to better predict the future evolutionary path of these viruses.

His research focus also aims to understand how host immune system elicits antibodies against the conserved epitopes of influenza A virus major surface glycoprotein hemagglutinin (HA) after infection or vaccination. Antibodies to these conserved regions of HA can be used as prophylaxis for the elderly, pediatric and immune compromised patients (i.e., infected with HIV or other conditions that impairs their immune system). Based on the epitopes of cross-reactive antibodies, he hopes to formulate new vaccine candidate that elicit immune response to the conserve regions and protect from both seasonal and pandemic influenza viruses.  Overall, his ultimate research efforts are not only seek to improve the prediction of vaccine formulations but also help to generate universal flu vaccine.

Select Publications

Das SR, Hensley SE, et al.
Defining Influenza A Virus Hemagglutinin Antigenic Drift by Sequential Monoclonal Antibody Selection.

Cell Host & Microbe. 2013 Mar 13; 13: 314-23.[more]

Harris AK, Meyerson JR, et al.
Structure and Accessibility of HA Trimers on Intact 2009 H1N1 Pandemic Influenza Virus to Stem Region-specific Neutralizing Antibodies.

Proceedings of the National Academy of Sciences of the United States of America. 2013 Mar 04;[more]

O'Donnell CD, Vogel L, et al.
Antibody Pressure by a Human Monoclonal Antibody Targeting the 2009 Pandemic H1N1 Virus Hemagglutinin Drives the Emergence of a Virus With Increased Virulence In Mice.

mBio. 2012 Jun 01; 3[more]

Li GM, Chiu C, et al.
Pandemic H1N1 Influenza Vaccine Induces a Recall Response In Humans That Favors Broadly Cross-reactive Memory B Cells.

Proceedings of the National Academy of Sciences of the United States of America. 2012 May 21;[more]

Das SR, Hensley SE, et al.
Fitness Costs Limit Influenza A Virus Hemagglutinin Glycosylation as an Immune Evasion Strategy.

Proceedings of the National Academy of Sciences of the United States of America. 2011 Dec 20; 108: E1417-22.[more]

Hensley, S. E., Das, S. R., et al.
Influenza A Virus Hemagglutinin Antibody Escape Promotes Neuraminidase Antigenic Variation and Drug Resistance

PLoS One. 2011 Feb 06; 6(2): e15190.[more]

Wrammert, J., Koutsonanos, D., et al.
Broadly Cross-reactive Antibodies Dominate the Human B Cell Response Against 2009 Pandemic H1N1 Influenza Virus Infection

J Exp Med. 2011 Jan 17; 208(1): 181-93.[more]

Das, S. R., Puigbo, P., et al.
Glycosylation Focuses Sequence Variation In the Influenza A Virus H1 Hemagglutinin Globular Domain

PLoS Pathog. 2010 Nov 01; 6(11): e1001211.[more]

Netzer, N., Goodenbour, J. M., et al.
Innate Immune and Chemically Triggered Oxidative Stress Modifies Translational Fidelity

Nature. 2009 Nov 26; 462(7272): 522-6.[more]

Hensley, S. E., Das, S. R., et al.
Hemagglutinin Receptor Binding Avidity Drives Influenza A Virus Antigenic Drift

Science. 2009 Oct 30; 326(5953): 734-6.[more]

Lev A, Dimberu P, et al.
Efficient Cross-priming of Antiviral CD8+ T Cells by Antigen Donor Cells Is GRP94 Independent.

Journal of immunology (Baltimore, Md. : 1950). 2009 Oct 01; 183: 4205-10.[more]

Chaudhry, A., Das, S. R., et al.
HIV-1 Nef Induces a Rab11-dependent Routing of Endocytosed Immune Costimulatory Proteins CD80 and CD86 to the Golgi

Traffic. 2008 Nov 01; 9(11): 1925-35.[more]

Chaudhry, A., Das, S. R., et al.
A Two-pronged Mechanism for HIV-1 Nef-mediated Endocytosis of Immune Costimulatory Molecules CD80 and CD86

Cell Host Microbe. 2007 Mar 15; 1(1): 37-49.[more]

Chaudhry, A., Das, S. R., et al.
The Nef Protein of HIV-1 Induces Loss of Cell Surface Costimulatory Molecules CD80 and CD86 In APCs

J Immunol. 2005 Oct 01; 175(7): 4566-74.[more]

Das, S. R., Jameel, S.
Biology of the HIV Nef Protein

Indian J Med Res. 2005 Apr 01; 121(4): 315-32.[more]