About
Biographies
Research Interests and Accomplishments
Dr. Shiliang Wang is a Senior Bioinformatics Analyst at the J. Craig Venter Institute focused on viral genomics studies. His current research interests include developing tools for viral gene prediction of small RNA viral genomes, visualization of sequence polymorphisms in large viral gene families, and studying the genome evolutionary path of small RNA viruses, especially influenza virus and rhinovirus.
He developed VIGOR (Viral Genome ORF Reader), which has the capability to accurately predict genes for more than fifteen different viruses and is used as the major gene calling tool for the GSCID (Genome Sequencing Center for Infectious Diseases) project since 2004. He has been following the mutation trend of SOIV H1N1 since it was first detected in humans in 2009.
Before he started to work on viral genomics, Dr. Wangââ"š¬Ã¢"ž¢s research was focusing on nematode genomics at TIGR (The Institute of Genomics Research). He played a critical role in the complete genome sequencing of Brugia malayi, a pathogenic nematode parasite found in humans. There are millions of new patients each year worldwide infected by this parasite, the majority of which are found in Africa, Latin America, and South Asia.
Dr. Wang was employed as a Bioinformatics Analyst at Integrated Genomics Ltd in Chicago, Illinois before he joined TIGR in 2002. He earned his Ph.D. at Rutgers University where he focused on molecular genetics in C. elegans.
Select Publications
Wang S, Sundaram JP, et al.
VIGOR Extended to Annotate Genomes for Additional 12 Different Viruses.
Nucleic acids research. 2012 Jul 01; 40: W186-92.[more]
Shiliang Wang, Haifeng Chen, et al.
Omics, Microbial Modeling and Technologies for Foodborne Pathogens
2012 Jan 01;: 233-268, 579-602.[more]
Vlasova, A. N., Halpin, R., et al.
Molecular Characterization of a New Species In the Genus Alphacoronavirus Associated With Mink Epizootic Catarrhal Gastroenteritis.
The Journal of general virology. 2011 Jun 01; 92(0): 1369-79.[more]
Wang, S., Sundaram, J. P., et al.
VIGOR, an Annotation Program for Small Viral Genomes
BMC Bioinformatics. 2010 Sep 07; 11(1): 451.[more]
McDonald, S. M., Matthijnssens, J., et al.
Evolutionary Dynamics of Human Rotaviruses: Balancing Reassortment With Preferred Genome Constellations
PLoS Pathog. 2009 Oct 01; 5(10): e1000634.[more]
Palmenberg, A. C., Spiro, D., et al.
Sequencing and Analyses of All Known Human Rhinovirus Genomes Reveal Structure and Evolution
Science. 2009 Apr 03; 324(5923): 55-9.[more]
Alekseev, K. P., Vlasova, A. N., et al.
Bovine-Like Coronaviruses Isolated From Four Species Of Captive Wild Ruminants Are Homologous To Bovine Coronaviruses Based On Complete Genomic Sequences
J Virol. 2008 Oct 08; 82(24): 12422-31.[more]
Kumar, S., Chaudhary, K., et al.
Mining Predicted Essential Genes of Brugia malayi for Nematode Drug Targets
PLoS ONE. 2007 Nov 14; 2(11): e1189.[more]
Ghedin, E., Wang, S., et al.
Draft Genome of the Filarial Nematode Parasite Brugia malayi
Science. 2007 Sep 21; 317(5845): 1756-60.[more]
Hotopp, J. C., Clark, M. E., et al.
Widespread Lateral Gene Transfer from Intracellular Bacteria to Multicellular Eukaryotes
Science. 2007 Aug 30;[more]
Zhang, X., Hasoksuz, M., et al.
Quasispecies of Bovine Enteric and Respiratory Coronaviruses Based on Complete Genome Sequences and Genetic Changes After Tissue Culture Adaptation
Virology. 2007 Jun 20; 363(1): 1-10.[more]
Hasoksuz, M., Alekseev, K., et al.
Biologic, Antigenic, and Full-length Genomic Characterization of a Bovine-like Coronavirus Isolated from a Giraffe
J Virol. 2007 May 01; 81(10): 4981-90.[more]
Zhang, X., Hasoksuz, M., et al.
Complete Genomic Sequences, a Key Residue In the Spike Protein and Deletions In Nonstructural Protein 3b of US Strains of the Virulent and Attenuated Coronaviruses, Transmissible Gastroenteritis Virus and Porcine Respiratory Coronavirus
Virology. 2007 Feb 20; 358(2): 424-35.[more]
Berriman, M., Ghedin, E., et al.
The Genome of the African Trypanosome Trypanosoma brucei
Science. 2005 Jul 15; 309(5733): 416-22.[more]
Foster, J., Ganatra, M., et al.
The Wolbachia Genome of Brugia Malayi: Endosymbiont Evolution Within a Human Pathogenic Nematode
PLoS Biol. 2005 Mar 29; 3(4): e121.[more]
Ghedin, E., Wang, S. L., et al.
First Sequenced Genome of a Parasitic Nematode
Trends in Parasitology. 2004 Apr 01; 20(4): 151-153.[more]