JCVI: About / Bios / William C. Nierman
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William C. Nierman, Ph.D.

Research Interests and Accomplishments

Dr. William Nierman is an Infectious Disease Investigator at the J. Craig Venter Institute (JCVI).  He is also Professor of Biochemistry and Molecular biology at The George Washington University School of Medicine. He received his B.S. degree from the US Naval Academy and his Ph.D. degree from the University of California Berkeley. Prior to joining JCVI he mapped human ESTs to the human genome with some of this work done in collaboration with Craig Venter.

Dr. Nierman's current research focus is on genomic and functional analysis of two levels of interaction between microbial pathogens and the human host immune system. Burkholderia mallei and Burkholderia pseudomallei are severe bacterial pathogens that cause difficult to diagnose but very life threatening diseases and are classified as select agents by CDC.

At the other end of the pathogenicity scale are Aspergillus and Penicillium fungal pathogens which cause invasive or systemic disease in immune compromised or immune suppressed human hosts. Both groups of organisms pose serious public health issues in both developed and in developing countries.

Select Publications

Losada L, Barker BM, et al.
Large-Scale Transcriptional Response to Hypoxia in Aspergillus fumigatus Observed Using RNAseq Identifies a Novel Hypoxia Regulated NcRNA.

Mycopathologia. 2014 Jul 05;[more]

Dugan VG, Emrich SJ, et al.
Standardized Metadata for Human Pathogen/Vector Genomic Sequences.

PloS One. 2014 Jun 01; 9: e99979.[more]

Vipond J, Kane J, et al.
Sequence Determination of Burkholderia pseudomallei Strain NCTC 13392 Colony Morphology Variants.

Genome Announcements. 2013 Feb 01; 1[more]

Varga JJ, Losada L, et al.
Draft Genome Sequences of Burkholderia cenocepacia ET12 Lineage Strains K56-2 and BC7.

Genome Announcements. 2013 Feb 01; 1[more]

Joardar V, Abrams NF, et al.
Sequencing of Mitochondrial Genomes of Nine Aspergillus and Penicillium Species Identifies Mobile Introns and Accessory Genes as Main Sources of Genome Size Variability.

BMC Genomics. 2012 Sep 01; 13: 698.[more]

Fedorova, N. D., Khaldi, N., et al.
Genomic Islands In the Pathogenic Filamentous Fungus Aspergillus fumigatus

PLoS Genet. 2008 Apr 01; 4(4): e1000046.[more]

Bhabhra, R., Richie, D. L., et al.
Impaired Ribosome Biogenesis Disrupts the Integration Between Morphogenesis and Nuclear Duplication During the Germination of Aspergillus fumigatus

Eukaryot Cell. 2008 Feb 22; 7(4): 575-83.[more]

Schell, M. A., Ulrich, R. L., et al.
Type VI Secretion Is a Major Virulence Determinant In Burkholderia mallei

Mol Microbiol. 2007 Jun 01; 64(6): 1466-85.[more]

Perrin, R. M., Fedorova, N. D., et al.
Transcriptional Regulation of Chemical Diversity In Aspergillus fumigatus by LaeA

PLoS Pathog. 2007 Apr 01; 3(4): e50.[more]

Tiyawisutsri, R., Holden, M. T., et al.
Burkholderia Hep_Hap Autotransporter (BuHA) Proteins Elicit a Strong Antibody Response During Experimental Glanders but Not Human Melioidosis

BMC Microbiol. 2007 Mar 15; 7(1): 19.[more]

Rokas, A., Payne, G., et al.
What Can Comparative Genomics Tell Us About Species Concepts In the Genus Aspergillus?

Stud Mycol. 2007 Jan 01; 59: 11-7.[more]