JCVI: About / Bios / William C. Nierman
Section Banner



William C. Nierman, Ph.D.
Director Infectious Diseases Program

Research Focus

Respiratory tract microbiome (RT) in health and disease

  • The role of the RT microbiome in preventing or increasing susceptibility to infections
  • The interactions of the RT microbiome, the host immune system, and respiratory pathogens
  • Innate immune system defects and the RT microbiome in microbial colonization and infection

Burkholderia pseudomallei and B. mallei genomics

  • The role of B. pseudomallei persisters in melioidosis drug resistance and reemergence
  • Evolution of virulence in B. mallei and B. pseudomallei

Genomic analysis of Aspergillus fumigatus in human aspergillosis

  • Genomic analysis of Aspergillus virulence and drug resistance
  • Comparative genomic analysis in the genus Aspergillus

Education and Training

  • Postdoctoral Fellow, University of California San Francisco
  • Ph.D. Biochemistry, University of California, Berkeley
  • M.S. Organic Chemistry, Naval Postgraduate School
  • B.S. Chemistry, U.S. Naval Academy

Select Publications

Dugan VG, Emrich SJ, et al.
Standardized Metadata for Human Pathogen/vector Genomic Sequences.

PloS One. 2014 Dec 01; 9: e99979.[more]

Joardar V, Abrams NF, et al.
Sequencing of Mitochondrial Genomes of Nine Aspergillus and Penicillium Species Identifies Mobile Introns and Accessory Genes as Main Sources of Genome Size Variability.

BMC Genomics. 2012 Sep 01; 13: 698.[more]

Bhabhra, R., Richie, D. L., et al.
Impaired Ribosome Biogenesis Disrupts the Integration Between Morphogenesis and Nuclear Duplication During the Germination of Aspergillus fumigatus

Eukaryot Cell. 2008 Feb 22; 7(4): 575-83.[more]

Schell, M. A., Ulrich, R. L., et al.
Type VI Secretion Is a Major Virulence Determinant In Burkholderia mallei

Mol Microbiol. 2007 Jun 01; 64(6): 1466-85.[more]

Perrin, R. M., Fedorova, N. D., et al.
Transcriptional Regulation of Chemical Diversity In Aspergillus fumigatus by LaeA

PLoS Pathog. 2007 Apr 01; 3(4): e50.[more]

Tiyawisutsri, R., Holden, M. T., et al.
Burkholderia Hep_Hap Autotransporter (BuHA) Proteins Elicit a Strong Antibody Response During Experimental Glanders but Not Human Melioidosis

BMC Microbiol. 2007 Mar 15; 7(1): 19.[more]

Rokas, A., Payne, G., et al.
What Can Comparative Genomics Tell Us About Species Concepts In the Genus Aspergillus?

Stud Mycol. 2007 Jan 01; 59: 11-7.[more]