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About

Biographies

Yanbao Yu, Ph.D.
Staff Scientist

Research Focus

Develop novel mass spectrometry-based techniques for efficient and high throughput proteome identification and quantification

  • Alternative protein and peptide separation technologies
  • Large scale clinical/microbial sample preparation for biomarker discovery and clinical diagnosis
  • Novel sample processing methods for shotgun proteomics
  • Label-based and label-free proteome quantitation

Study microbiomes and their participation in human physiology with metaproteomic approaches

  • MS-based microbial identification (e.g., from urinary tract) as potential clinical diagnostic method
  • Mechanism of host-pathogen interactions in infectious diseases
  • Protein complex and protein-protein interaction
  • Integration of proteomics and metabolomics

Education and Training

  • Postdoctoral Associate, Proteomics and Biochemistry, UNC at Chapel Hill
  • Ph.D. Chemical Biology, Fudan University

Select Publications

Yu Y, Sikorski P, et al.
Comprehensive Metaproteomic Analyses of Urine in the Presence and Absence of Neutrophil-Associated Inflammation in the Urinary Tract.

Theranostics. 2017 Jan 01; 7: 238-252.[more]

Yu Y, Kwon K, et al.
Characterization of Early-Phase Neutrophil Extracellular Traps in Urinary Tract Infections.

PLoS Pathogens. 2017 Jan 01; 13: e1006151.[more]

Yu Y, Sikorski P, et al.
Diagnosing Inflammation and Infection in the Urinary System via Proteomics.

Journal of Translational Medicine. 2015 Dec 01; 13: 111.[more]

Yu Y, Zielinski MD, et al.
Similar Neutrophil-Driven Inflammatory and Antibacterial Responses in Elderly Patients With Symptomatic and Asymptomatic Bacteriuria.

Infection and Immunity. 2015 Oct 01; 83: 4142-53.[more]

Yu Y, Pieper R
Urinary Pellet Sample Preparation for Shotgun Proteomic Analysis of Microbial Infection and Host-pathogen Interactions.

Methods in Molecular Biology (Clifton, N.J.). 2015 Apr 01; 1295: 65-74.[more]

Yu Y, Pieper R
Urine Sample Preparation in 96-well Filter Plates to Characterize Inflammatory and infectious Diseases of the Urinary Tract.

Advances in Experimental Medicine and Biology. 2015 Apr 01; 845: 77-87.[more]

Suh MJ, Kuntumalla S, et al.
Proteomes of Pathogenic Escherichia Coli/Shigella Group Surveyed in Their Host Environments.

Expert Review of Proteomics. 2014 Oct 01; 11: 593-609.[more]

Yu Y, Suh MJ, et al.
Urine Sample Preparation in 96-well Filter Plates for Quantitative Clinical Proteomics.

Analytical Chemistry. 2014 Jun 03; 86: 5470-7.[more]

Liu C, Yu Y, et al.
A Chromatin Activity-based Chemoproteomic Approach Reveals a Transcriptional Repressome for Gene-specific Silencing.

Nature Communications. 2014 Apr 01; 5: 5733.[more]

Khatun J, Yu Y, et al.
Whole Human Genome Proteogenomic Mapping for ENCODE Cell Line Data: Identifying Protein-coding Regions.

BMC Genomics. 2013 May 01; 14: 141.[more]

Yu Y, Xie L, et al.
GOFAST: an Integrated Approach for Efficient and Comprehensive Membrane Proteome Analysis.

Analytical Chemistry. 2012 Nov 06; 84: 9008-14.[more]

Lee YY, Yu YB, et al.
BCLAF1 Is a Radiation-induced H2AX-interacting Partner Involved in ?H2AX-mediated Regulation of Apoptosis and DNA Repair.

Cell Death & Disease. 2012 May 01; 3: e359.[more]

Yu Y, Leng T, et al.
Global Analysis of the Rat and Human Platelet Proteome - the Molecular Blueprint for Illustrating Multi-functional Platelets and Cross-species Function Evolution.

Proteomics. 2010 Jul 01; 10: 2444-57.[more]

Liang S, Yu Y, et al.
Analysis of the Protein Complex Associated With 14-3-3 Epsilon by a Deuterated-leucine Labeling Quantitative Proteomics Strategy.

Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences. 2009 Mar 01; 877: 627-34.[more]