JCVI: About / Bios / Yanbao Yu
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Yanbao Yu, Ph.D.
Staff Scientist

Research Focus

Develop novel mass spectrometry-based techniques for efficient and high throughput proteome identification and quantification

  • Alternative protein and peptide separation technologies
  • Large scale clinical/microbial sample preparation for biomarker discovery and clinical diagnosis
  • Novel sample processing methods for shotgun proteomics
  • Label-based and label-free proteome quantitation

Study microbiomes and their participation in human physiology with metaproteomic approaches

  • MS-based microbial identification (e.g., from urinary tract) as potential clinical diagnostic method
  • Mechanism of host-pathogen interactions in infectious diseases
  • Protein complex and protein-protein interaction
  • Integration of proteomics and metabolomics

Education and Training

  • Postdoctoral Associate, Proteomics and Biochemistry, UNC at Chapel Hill
  • Ph.D. Chemical Biology, Fudan University

Select Publications

Yan J, Yan F, et al.
The 3M Complex Maintains Microtubule and Genome Integrity.

Molecular Cell. 2014 Apr 30;[more]

Lane KR, Yu Y, et al.
Cell Cycle-regulated Protein Abundance Changes in Synchronously Proliferating HeLa Cells Include Regulation of Pre-mRNA Splicing Proteins.

PloS One. 2013 May 01; 8: e58456.[more]

Khatun J, Yu Y, et al.
Whole Human Genome Proteogenomic Mapping for ENCODE Cell Line Data: Identifying Protein-coding Regions.

BMC Genomics. 2013 May 01; 14: 141.[more]

Xie L, Liu C, et al.
Protein Phosphatase 2A Catalytic Subunit α Plays a MyD88-dependent, Central Role in the Gene-specific Regulation of Endotoxin Tolerance.

Cell Reports. 2013 Mar 28; 3: 678-88.[more]

Yu Y, Xie L, et al.
GOFAST: an Integrated Approach for Efficient and Comprehensive Membrane Proteome Analysis.

Analytical Chemistry. 2012 Nov 06; 84: 9008-14.[more]

Bánfai B, Jia H, et al.
Long Noncoding RNAs Are Rarely Translated in Two Human Cell Lines.

Genome Research. 2012 Sep 01; 22: 1646-57.[more]

Huang W, Sun W, et al.
Incorporation of a Fluorous Diazirine Group Into Phosphatidylinositol 4,5-bisphosphate to Illustrate Its Interaction With ADP-ribosylation Factor 1.

Organic & Biomolecular Chemistry. 2012 Jul 21; 10: 5197-201.[more]

Lei Y, Wen H, et al.
The Mitochondrial Proteins NLRX1 and TUFM Form a Complex That Regulates Type I Interferon and Autophagy.

Immunity. 2012 Jun 29; 36: 933-46.[more]

Lee YY, Yu YB, et al.
BCLAF1 Is a Radiation-induced H2AX-interacting Partner Involved in γH2AX-mediated Regulation of Apoptosis and DNA Repair.

Cell Death & Disease. 2012 May 01; 3: e359.[more]

Jing L, Parker CE, et al.
Discovery of Biomarker Candidates for Coronary Artery Disease from an APOE-knock Out Mouse Model Using ITRAQ-based Multiplex Quantitative Proteomics.

Proteomics. 2011 Jul 01; 11: 2763-76.[more]

Huang Y, Shi Q, et al.
An Optimized Magnetite Microparticle-based Phosphopeptide Enrichment Strategy for Identifying Multiple Phosphorylation Sites in an Immunoprecipitated Protein.

Analytical Biochemistry. 2011 Jan 01; 408: 19-31.[more]

Leng T, Liu N, et al.
Dissection of DEN-induced Platelet Proteome Changes Reveals the Progressively Dys-regulated Pathways Indicative of Hepatocarcinogenesis.

Journal of Proteome Research. 2010 Dec 03; 9: 6207-19.[more]

Yu Y, Leng T, et al.
Global Analysis of the Rat and Human Platelet Proteome - the Molecular Blueprint for Illustrating Multi-functional Platelets and Cross-species Function Evolution.

Proteomics. 2010 Jul 01; 10: 2444-57.[more]

Song P, Bao H, et al.
Comprehensive Profiling of Metastasis-related Proteins in Paired Hepatocellular Carcinoma Cells With Different Metastasis Potentials.

Proteomics. Clinical Applications. 2009 Jul 01; 3: 841-52.[more]

Wilcox KC, Zhou L, et al.
Modifications of Superoxide Dismutase (SOD1) in Human Erythrocytes: a Possible Role in Amyotrophic Lateral Sclerosis.

The Journal of Biological Chemistry. 2009 May 15; 284: 13940-7.[more]

Dai P, Jeong SY, et al.
Modulation of TLR Signaling by Multiple MyD88-interacting Partners Including Leucine-rich Repeat Fli-I-interacting Proteins.

Journal of Immunology (Baltimore, Md. : 1950). 2009 Mar 15; 182: 3450-60.[more]

Liang S, Yu Y, et al.
Analysis of the Protein Complex Associated With 14-3-3 Epsilon by a Deuterated-leucine Labeling Quantitative Proteomics Strategy.

Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences. 2009 Mar 01; 877: 627-34.[more]

Xie L, Jing L, et al.
In Vivo Profiling Endogenous Interactions With Knock-out in Mammalian Cells.

Analytical Chemistry. 2009 Feb 15; 81: 1411-7.[more]

Xue Y, Yun D, et al.
Proteomic Dissection of Agonist-specific TLR-mediated Inflammatory Responses on Macrophages at Subcellular Resolution.

Journal of Proteome Research. 2008 Aug 01; 7: 3180-93.[more]

Chen X, Sun L, et al.
Amino Acid-coded Tagging Approaches in Quantitative Proteomics.

Expert Review of Proteomics. 2007 Feb 01; 4: 25-37.[more]