A Multi-omic Systems-based Approach Reveals Metabolic Markers of Bacterial Vaginosis and Insight Into the Disease.
PloS One. 2013 Feb 01; 8: e56111.
Bacterial vaginosis (BV) is the most common vaginal disorder of reproductive-age women. Yet the cause of BV has not been established. To uncover key determinants of BV, we employed a multi-omic, systems-biology approach, including both deep 16S rRNA gene-based sequencing and metabolomics of lavage samples from 36 women. These women varied demographically, behaviorally, and in terms of health status and symptoms.