JCVI: A Novel Method of Consensus Pan-chromosome Assembly and Large-scale Comparative Analysis Reveal the Highly Flexible Pan-genome of Acinetobacter Baumannii.
 
 
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Chan AP, Sutton G, Depew J, Krishnakumar R, Choi Y, Huang XZ, Beck E, Harkins DM, Kim M, Lesho EP, Nikolich MP, Fouts DE

A Novel Method of Consensus Pan-chromosome Assembly and Large-scale Comparative Analysis Reveal the Highly Flexible Pan-genome of Acinetobacter Baumannii.

Genome Biology. 2015 Jul 21; 16: 143.

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Abstract

Infections by pan-drug resistant Acinetobacter baumannii plague military and civilian healthcare systems. Previous A. baumannii pan-genomic studies used modest sample sizes of low diversity and comparisons to a single reference genome, limiting our understanding of gene order and content. A consensus representation of multiple genomes will provide a better framework for comparison. A large-scale comparative study will identify genomic determinants associated with their diversity and adaptation as a successful pathogen.