JCVI: Adaptation of Pandemic H2N2 Influenza A Viruses in Humans.
 
 
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Citation

Joseph U, Linster M, Suzuki Y, Krauss S, Halpin RA, Vijaykrishna D, Fabrizio TP, Bestebroer TM, Maurer-Stroh S, Webby RJ, Wentworth DE, Fouchier RA, Bahl J, Smith GJ

Adaptation of Pandemic H2N2 Influenza A Viruses in Humans.

Journal of Virology. 2015 Feb 15; 89: 2442-7.

External Citation

Abstract

The 1957 A/H2N2 influenza virus caused an estimated 2 million fatalities during the pandemic. Since viruses of the H2 subtype continue to infect avian species and pigs, the threat of reintroduction into humans remains. To determine factors involved in the zoonotic origin of the 1957 pandemic, we performed analyses on genetic sequences of 175 newly sequenced human and avian H2N2 virus isolates and all publicly available influenza virus genomes.