Huang ZP, Seok HY, Zhou B, Chen J, Chen JF, Tao Y, Pu WT, Wang DZ, Young Seok H
CIP, a cardiac Isl1-interacting protein, represses cardiomyocyte hypertrophy.
Circulation research. 2012 Mar 16; 110: 818-30.
Mammalian heart has minimal regenerative capacity. In response to mechanical or pathological stress, the heart undergoes cardiac remodeling. Pressure and volume overload in the heart cause increased size (hypertrophic growth) of cardiomyocytes. Whereas the regulatory pathways that activate cardiac hypertrophy have been well-established, the molecular events that inhibit or repress cardiac hypertrophy are less known.