Luo S, Zhao L, Wang J, Xu M, Li J, Zhou B, Xiao F, Long X, Shi M
Clinical Outcome for Early-stage Nasopharyngeal Carcinoma With Predominantly WHO II Histology Treated by Intensity-modulated Radiation Therapy With or Without Chemotherapy In Non-endemic Region of China.
Head & Neck. 2013 May 29;
Background: The clinical outcomes of early-stage nasopharyngeal carcinoma (NPC) in Northwest China were evaluated. Methods and Materials: A retrospective study was performed from 69 NPC patients treated with IMRT with or without chemotherapy. Results: Median follow-up was 34 months. WHO II was the predominant histology (71%). All treatment failures occurred in T2N1 NPCs (14.5 %) with metastasis the major reason. The 3-year overall survival, local recurrence-free survival, distant metastasis-free survival were 93.3%, 94.1%, 94.8% respectively. The 3-year survival rate for T2N1 and IMRT alone group were both significantly poorer than T1N0, T2N0 and T1N1 group and chemoradiation group respectively (P<0.05). N1 classification, T2N1 stage and addition of chemoradiation were significant independent predictors (P < 0.05). No grade IV toxicities were observed. Conclusions: T2N1 stage is a unique subgroup with higher risk of distant metastasis. Improved outcomes of T2N1 NPC with predominantly WHO II histology after chemoradiation has not beent reported. © 2013 Wiley Periodicals, Inc. Head Neck, 2013.