Krampis K, Booth T, Chapman B, Tiwari B, Bicak M, Field D, Nelson KE
Cloud BioLinux: Pre-configured and On-demand Bioinformatics Computing for the Genomics Community.
BMC bioinformatics. 2012 Dec 01; 13: 42.
A steep drop in the cost of next-generation sequencing during recent years has made the technology affordable to the majority of researchers, but downstream bioinformatic analysis still poses a resource bottleneck for smaller laboratories and institutes that do not have access to substantial computational resources. Sequencing instruments are typically bundled with only the minimal processing and storage capacity required for data capture during sequencing runs. Given the scale of sequence datasets, scientific value cannot be obtained from acquiring a sequencer unless it is accompanied by an equal investment in informatics infrastructure.