JCVI: Comprehensive Analysis of Treatment Response Phenotypes in Rheumatoid Arthritis for Pharmacogenetic Studies.
 
 
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Citation

Standish KA, Huang CC, Curran ME, Schork NJ

Comprehensive Analysis of Treatment Response Phenotypes in Rheumatoid Arthritis for Pharmacogenetic Studies.

Arthritis Research & Therapy. 2017 May 12; 19: 90.

External Citation

Abstract

An individual patient's response to a particular drug is influenced by multiple factors, which may include genetic predisposition. Pharmacogenetic studies attempt to discover and estimate the contributions of genetic variants to the variability in response to a drug treatment. The task of identifying the genetic contribution is often complicated by response phenotypes that are based on imprecise or subjective clinical observations. Because the success of a pharmacogenetic study depends on the analysis of a heritable phenotype, it is important to identify phenotypes with a significant heritable component to ensure reliable and reproducible results in subsequent genetic association studies.