Bai J, Zhong X, Tang H, He Z, Zhang J, Deng J
[Effect of Integrin ÃŽÂ±5ÃŽÂ²1-mediated ERK Signal Pathway on Proliferation and Migration of A549 Cells].
Zhongguo fei ai za zhi = Chinese journal of lung cancer. 2011 Jul 01; 14: 568-74.
Recent studies have shown that integrin ÃŽÂ±5ÃŽÂ²1 as a core in the integrin family plays an important role in metastasis, invasion and poor difference of non-small cell lung cancer. In this study, A549 cells were cultured and treated with integrin ÃŽÂ±5ÃŽÂ²1 small interfering RNA (siRNA) and extracelluar signal-regulated protein kinase (ERK) inhibitor PD98059 to investigate the effect of integrin ÃŽÂ±5ÃŽÂ²1 on proliferation and migration of A549 cells and explore its signal transduction mechanism.