JCVI: [Effect of Integrin α5β1-mediated ERK Signal Pathway on Proliferation and Migration of A549 Cells].
 
 
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Citation

Bai J, Zhong X, Tang H, He Z, Zhang J, Deng J

[Effect of Integrin α5β1-mediated ERK Signal Pathway on Proliferation and Migration of A549 Cells].

Zhongguo fei ai za zhi = Chinese journal of lung cancer. 2011 Jul 01; 14: 568-74.

External Citation

Abstract

Recent studies have shown that integrin α5β1 as a core in the integrin family plays an important role in metastasis, invasion and poor difference of non-small cell lung cancer. In this study, A549 cells were cultured and treated with integrin α5β1 small interfering RNA (siRNA) and extracelluar signal-regulated protein kinase (ERK) inhibitor PD98059 to investigate the effect of integrin α5β1 on proliferation and migration of A549 cells and explore its signal transduction mechanism.