Bartha I, McLaren PJ, Brumme C, Harrigan R, Telenti A, Fellay J
Estimating the Respective Contributions of Human and Viral Genetic Variation to HIV Control.
PLoS Computational Biology. 2017 Feb 01; 13: e1005339.
We evaluated the fraction of variation in HIV-1 set point viral load attributable to viral or human genetic factors by using joint host/pathogen genetic data from 541 HIV infected individuals. We show that viral genetic diversity explains 29% of the variation in viral load while host factors explain 8.4%. Using a joint model including both host and viral effects, we estimate a total of 30% heritability, indicating that most of the host effects are reflected in viral sequence variation.