Seshadri, R., Joseph, S. W., Chopra, A. K., Sha, J., Shaw, J., Graf, J., Haft, D., Wu, M., Ren, Q., Rosovitz, M. J., Madupu, R., Tallon, L., Kim, M., Jin, S., Vuong, H., Stine, C. O., Ali, A., Horneman, A. J., Heidelberg, J. F.
Genome Sequence of Aeromonas hydrophila ATCC 7966T: The Jack of All Trades
J Bacteriol. 2006 Sep 15; 188: 8272-8282.
The complete genome of Aeromonas hydrophila ATCC 7966(T) was sequenced. Aeromonas, a ubiquitous water-borne bacterium, has been placed by the Environmental Protection Agency on the "Contaminant Candidate List" because of its potential to cause human disease. The 4.7 Mb genome of this emerging pathogen illustrates a physiologically adroit organism with broad metabolic capabilities and considerable virulence potential. A large array of virulence genes, including ones identified in clinical isolates of Aeromonas spp. or Vibrio spp., may confer the ability of this organism to infect a wide range of hosts. However, two recognized virulence markers, a type III secretion system and a lateral flagella, that are reported in other A. hydrophila strains, are not identified in the sequenced isolate, ATCC 7966(T). Given the ubiquity and free-living lifestyle of this organism, there is relatively little evidence of fluidity in terms of mobile elements in the genome of this particular strain. Notable aspects of the metabolic repertoire of A. hydrophila include dissimilatory sulfate reduction and resistance mechanisms (such as thiopurine reductase, arsenate reductase, phosphonate degradation enzymes) against toxic compounds encountered in polluted waters. These enzymes may have bioremediative and industrial potential as well. Thus, the A. hydrophila genome sequence provides valuable insights into its ability to flourish in both aquatic and host environments.