Bateman, A., Haft, D. H.
HMM-based Databases In InterPro
Brief Bioinform. 2002 Sep 01; 3(3): 236-45.
Protein family databases are an important resource for protein annotation and understanding protein evolution and function. In recent years hidden Markov models (HMMs) have become one of the key technologies used for detection of members of these families. This paper reviews the Pfam, TIGRFAMs and SMART databases that use the profile-HMMs provided by the HMMER package.