JCVI: In Vivo Versus In Vitro Protein Abundance Analysis of Shigella dysenteriae Type 1 Reveals Changes In the Expression of Proteins Involved In Virulence, Stress and Energy Metabolism.
 
 
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Citation

Kuntumalla S, Zhang Q, Braisted JC, Fleischmann RD, Peterson SN, Donohue-Rolfe A, Tzipori S, Pieper R

In Vivo Versus In Vitro Protein Abundance Analysis of Shigella dysenteriae Type 1 Reveals Changes In the Expression of Proteins Involved In Virulence, Stress and Energy Metabolism.

BMC microbiology. 2011 Jun 01; 11: 147.

External Citation

Abstract

Shigella dysenteriae serotype 1 (SD1) causes the most severe form of epidemic bacillary dysentery. Quantitative proteome profiling of Shigella dysenteriae serotype 1 (SD1) in vitro (derived from LB cell cultures) and in vivo (derived from gnotobiotic piglets) was performed by 2D-LC-MS/MS and APEX, a label-free computationally modified spectral counting methodology.