JCVI: MeSHer: Identifying Biological Concepts In Microarray Assays Based on PubMed References and MESH Terms
 
 
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Djebbari, A., Karamycheva, S., Howe, E., Quackenbush, J.

MeSHer: Identifying Biological Concepts In Microarray Assays Based on PubMed References and MESH Terms

Bioinformatics. 2005 May 26; 21(15): 3324-6.

PubMed Citation

Abstract

SUMMARY: MeSHer uses a simple statistical approach to identify biological concepts in the form of Medical Subject Headings (MeSH terms) obtained from the PubMed database that are significantly overrepresented within the identified gene set relative to those associated with the overall collection of genes on the underlying DNA microarray platform. As a demonstration, we apply this approach to gene lists acquired from a published study of the effects of angiotensin II (Ang II) treatment on cardiac gene expression and demonstrate that this approach can aid in the interpretation of the resulting "significant" gene set. AVAILABILITY: The software is available at www.tm4.org. SUPPLEMENTARY INFORMATION: Results from analysis of significant genes from the published Angiotensis II study.